For research use only.
Catalog No.S3190 Synonyms: NSC-29409, 6-Methyladenosine, N-Methyladenosine
CAS No. 1867-73-8
N6-methyladenosine (m6A, NSC-29409, 6-Methyladenosine, N-Methyladenosine) is a base modified analog of adenosine and is found as a minor nucleoside in natural RNAs.
Selleck's N6-methyladenosine (m6A) has been cited by 11 publications
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(A) Comparison of ribose modification across the RNA species. Modified nucleosides of MRC-5 cells were aligned in terms of modification type and then RNA species. Data are presented as means ± STD, n = 3. (B) tRNA modification profiles of cancer tissues. Data are presented as means ± STD, n = 5.
Biochem Biophys Res Commun, 2016, 476(4):340-5.. N6-methyladenosine (m6A) purchased from Selleck.
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|Description||N6-methyladenosine (m6A, NSC-29409, 6-Methyladenosine, N-Methyladenosine) is a base modified analog of adenosine and is found as a minor nucleoside in natural RNAs.|
N6-Methyladenosine is an abundant modification in mRNA and is found within some viruses, and most eukaryotes including mammals, insects, plants and yeast. It is also found in tRNA, rRNA, and small nuclear RNA(snRNA) as well as several long non-coding RNA, such as Xist.    N6-Methyladenosine is an endogenous urinary nucleoside product of the degradation of transfer ribonucleic acid (tRNA).  N6-Methyladenosine is a widespread RNA modification in many tissues with high levels in the brain. N6-Methyladenosine is enriched near stop codons and within 3’UTRs in both mouse and human mRNAs.  The recent discovery that FTO, an obesity risk gene, encodes an m6A demethylase implicates m6A as an important regulator of physiological processes. 
|In vivo||LD50: Mice >1g/kg (i.g.). |
-  Aloni Y, et al. J Virol, 1979, 32(1), 52-60.
-  Desrosiers R, et al. Proc Natl Acad Sci, 1974, 71(10), 3971-3975.
-  Adams JM, et al. Nature, 1975, 255(5503), 28-33.
|In vitro||DMSO||47 mg/mL (167.09 mM)|
|Water||14 mg/mL (49.77 mM)|
|Ethanol||2 mg/mL (7.11 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||NSC-29409, 6-Methyladenosine, N-Methyladenosine|
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).
Molecular Weight Calculator
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04696094||Recruiting||--||Moyamoya Disease||Beijing Tiantan Hospital||January 1 2021||--|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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