N6-methyladenosine (m6A)

For research use only.

Catalog No.S3190 Synonyms: NSC-29409, 6-Methyladenosine, N-Methyladenosine

11 publications

N6-methyladenosine (m6A) Chemical Structure

CAS No. 1867-73-8

N6-methyladenosine (m6A, NSC-29409, 6-Methyladenosine, N-Methyladenosine) is a base modified analog of adenosine and is found as a minor nucleoside in natural RNAs.

Selleck's N6-methyladenosine (m6A) has been cited by 11 publications

1 Customer Review

  • (A) Comparison of ribose modification across the RNA species. Modified nucleosides of MRC-5 cells were aligned in terms of modification type and then RNA species. Data are presented as means ± STD, n = 3. (B) tRNA modification profiles of cancer tissues. Data are presented as means ± STD, n = 5.
     

    Biochem Biophys Res Commun, 2016, 476(4):340-5.. N6-methyladenosine (m6A) purchased from Selleck.

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Biological Activity

Description N6-methyladenosine (m6A, NSC-29409, 6-Methyladenosine, N-Methyladenosine) is a base modified analog of adenosine and is found as a minor nucleoside in natural RNAs.
In vitro

N6-Methyladenosine is an abundant modification in mRNA and is found within some viruses, and most eukaryotes including mammals, insects, plants and yeast. It is also found in tRNA, rRNA, and small nuclear RNA(snRNA) as well as several long non-coding RNA, such as Xist. [1] [2] [3] N6-Methyladenosine is an endogenous urinary nucleoside product of the degradation of transfer ribonucleic acid (tRNA). [4] N6-Methyladenosine is a widespread RNA modification in many tissues with high levels in the brain. N6-Methyladenosine is enriched near stop codons and within 3’UTRs in both mouse and human mRNAs. [5] The recent discovery that FTO, an obesity risk gene, encodes an m6A demethylase implicates m6A as an important regulator of physiological processes. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CHO cells M{PBb2Z2dmO2aX;uJIF{e2G7 NFHNWXpKdmirYnn0bY9vKG:oIGuxNlVKZS2DQj3NSWNCKGKrbnTpcochfG9iaIXtZY4hSWSnbn;zbY5mKEF|IILlZ4VxfG:{IHX4dJJme3OnZDDpckBEUE9iY3XscJMtKEurPUmuN{BvVQ>? NY\jOY1tRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW3O|E1OjFpPkG1O|cyPDJzPD;hQi=>
CHO cells NI\DWGNHfW6ldHnvckBie3OjeR?= MoHVTY5pcWKrdHnvckBw\iCdM1jdVk1RUUFiYnnu[Ilv\yC2bzDoeY1idiCDZHXuc5NqdmViQUGgdoVk\XC2b4Kg[ZhxemW|c3XkJIlvKEOKTzDj[YxteyxiS3m9OkDPxE1? M{G1OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3N{exOFIyLz5zNUe3NVQzOTxxYU6=
CHO cells MV3GeY5kfGmxbjDhd5NigQ>? MkPuTY5pcWKrdHnvckBw\iCdMUK1TX1CSi2PRVPBJIJqdmSrbnegeI8hemG2IFHk[Y5we2mwZTDBN{Bz\WOncITvdkBmgHC{ZYPz[YQhcW5iQ1jPJINmdGy|LDDLbV03NjRizszN M3fRV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3N{exOFIyLz5zNUe3NVQzOTxxYU6=
adipocytes, heart and brain cells MYnGeY5kfGmxbjDhd5NigQ>? NUPST3U4SW[oaX7peJkh[2:wc4ThcpQh\m:{IHnubIljcXSrb36gc4YhSTFicnXj[ZB1d3JiY3;ueJJwdCCxZjDh[IVvgWyjdHWgZ5lkdGG|ZTDpckBi\Gmyb3P5eIV{NCCqZXHyeEBidmRiYoLhbY4h[2WubIOsJGFn\mmwaYT5JINwdnO2YX70QVAvOc7:TR?= MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek83Ojd7OESwK|43Ojd7OESwQE9iRg>?

... Click to View More Cell Line Experimental Data

In vivo LD50: Mice >1g/kg (i.g.). [7]

Protocol

Solubility (25°C)

In vitro DMSO 47 mg/mL (167.09 mM)
Water 14 mg/mL (49.77 mM)
Ethanol 2 mg/mL (7.11 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 281.27
Formula

C11H15N5O4

CAS No. 1867-73-8
Storage powder
in solvent
Synonyms NSC-29409, 6-Methyladenosine, N-Methyladenosine
Smiles CNC1=C2C(=NC=N1)N(C=N2)C3C(C(C(O3)CO)O)O

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04696094 Recruiting -- Moyamoya Disease Beijing Tiantan Hospital January 1 2021 --

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID