For research use only. Not for use in humans.
Catalog No.S3190 Synonyms: NSC-29409
Molecular Weight(MW): 281.27
N6-methyladenosine (m6A) is a base modified analog of adenosine and is found as a minor nucleoside in natural RNAs.
Selleck's N6-methyladenosine (m6A) has been cited by 5 publications
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(A) Comparison of ribose modification across the RNA species. Modified nucleosides of MRC-5 cells were aligned in terms of modification type and then RNA species. Data are presented as means ± STD, n = 3. (B) tRNA modification profiles of cancer tissues. Data are presented as means ± STD, n = 5.
Biochem Biophys Res Commun, 2016, 476(4):340-5.. N6-methyladenosine (m6A) purchased from Selleck.
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|Description||N6-methyladenosine (m6A) is a base modified analog of adenosine and is found as a minor nucleoside in natural RNAs.|
N6-Methyladenosine is an abundant modification in mRNA and is found within some viruses, and most eukaryotes including mammals, insects, plants and yeast. It is also found in tRNA, rRNA, and small nuclear RNA(snRNA) as well as several long non-coding RNA, such as Xist.    N6-Methyladenosine is an endogenous urinary nucleoside product of the degradation of transfer ribonucleic acid (tRNA).  N6-Methyladenosine is a widespread RNA modification in many tissues with high levels in the brain. N6-Methyladenosine is enriched near stop codons and within 3’UTRs in both mouse and human mRNAs.  The recent discovery that FTO, an obesity risk gene, encodes an m6A demethylase implicates m6A as an important regulator of physiological processes. 
|In vivo||LD50: Mice >1g/kg (i.g.). |
-  Aloni Y, et al. J Virol, 1979, 32(1), 52-60.
-  Desrosiers R, et al. Proc Natl Acad Sci, 1974, 71(10), 3971-3975.
-  Adams JM, et al. Nature, 1975, 255(5503), 28-33.
|In vitro||DMSO||47 mg/mL (167.09 mM)|
|Water||14 mg/mL (49.77 mM)|
|Ethanol||2 mg/mL (7.11 mM)|
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