Catalog No.S4738 Synonyms: Arctigenin-4-Glucoside, NSC 315527

For research use only.

Arctiin (Arctigenin-4-Glucoside, NSC 315527) acts on an agonists of the adiponectin receptor 1 with anti-cancer effects.

Arctiin Chemical Structure

CAS No. 20362-31-6

Purity & Quality Control

Choose Selective AdipoR Inhibitors

Biological Activity

Description Arctiin (Arctigenin-4-Glucoside, NSC 315527) acts on an agonists of the adiponectin receptor 1 with anti-cancer effects.
adiponectin receptor 1 [3]
In vitro

Arctiin induces growth inhibition and dephosphorylates the tumor-suppressor retinoblastoma protein in human immortalized keratinocyte HaCaT cells. The growth inhibition caused by arctiin is associated with the downregulation of cyclin D1 protein expression. The arctiin-induced suppression of cyclin D1 protein expression occurs in various types of human tumor cells, including osteosarcoma, lung, colorectal, cervical and breast cancer, melanoma, transformed renal cells and prostate cancer[1].

In vivo Arctiin has anti-cancer properties in animal models. arctiin has a remarkable anti-tumor-promoting effect as seen in a two-stage carcinogenesis test of mouse skin tumors induced by 7,12-dimethylbenz[α]anthracene(DMBA) as an initiator and 12-Otetradecanoyl phorbol-13-acetate (TPA) as a promoter by topical and oral administration. It also has a protective effect on 2-amino-1-methyl-6- phenylimidazo[4,5-β]pyridine (PhIP)-induced carcinogenesis particularly in the mammary gland during the promotion period[1]. Arctiin is orally effective against either IFV-inoculated normal or 5-fluorouracil (5-FU)-treated mice[3].

Protocol (from reference)

Cell Research:[1]
  • Cell lines: The human immortalized keratinocyte cell line HaCaT
  • Concentrations: 10, 25, 100 or 250 μM
  • Incubation Time: 1, 2 and 3 days
  • Method: HaCaT cells are plated at 1×105 cells in 25-mm-diameter dishes. Twenty-four hours after plating, various concentrations of arctiin are added to the culture medium. From the first to the third day after plating, the number of viable cells is counted by the trypan blue dye exclusion test.
  • (Only for Reference)
Animal Research:[2]
  • Animal Models: BALB/c mice
  • Dosages: 5.0 mg/ml
  • Administration: oral administration
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 100 mg/mL
(187.07 mM)
Ethanol 100 mg/mL
(187.07 mM)
Water 40 mg/mL
(74.82 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 534.55


CAS No. 20362-31-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles COC1=C(C=C(C=C1)CC2COC(=O)C2CC3=CC(=C(C=C3)OC4C(C(C(C(O4)CO)O)O)O)OC)OC

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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