Home Immunology & Inflammation ROS inhibitor L-SelenoMethionine

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L-SelenoMethionine ROS inhibitor

Cat.No.S3973

L-SelenoMethionine (SeMet), a naturally occurring amino acid, is a major food-form of selenium. It has been used as a supplement, and exhibits some important functions like cancer prevention and antioxidative defense.
L-SelenoMethionine ROS inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 196.11

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Chemical Information, Storage & Stability

Molecular Weight 196.11 Formula

C5H11NO2Se

 Storage (From the date of receipt)
CAS No. 3211-76-5 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles C[Se]CCC(C(=O)O)N

Solubility

In vitro
Batch:

Water : 39 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

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Mass Concentration Volume Molecular Weight

In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Mechanism of Action

In vitro
L-SelenoMethionine (SeMet) has also been shown to contribute to the mitigation of radiation-induced oxidative stress. This compound has the ability to selectively induce apoptosis and growth arrest in cancerous, but not normal, human prostate cells. Mechanistically, its treatment is shown to promote growth inhibition in human colon cancer cells through the phosphorylation of histone H3 via the activation of MAPK extracellular regulated kinase (ERK) and subsequent phosphorylation of the ribosomal S6 kinase (RSK)[1].
In vivo
L-SelenoMethionine (SeMet) increases survival time of NK/Ly lymphoma bearing animals treated with doxorubicin. This compound can effectively protect the hematopoietic system and liver of tumor-bearing animals with NK/Ly lymphoma from the side effects of anticancer drug doxorubicin, which is revealed by normalization of blood indexes, animal weight, and ALT/AST activity[2].
References

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