Home Immunology & Inflammation ROS inhibitor L-SelenoMethionine

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L-SelenoMethionine ROS inhibitor

Cat.No.S3973

L-SelenoMethionine (SeMet), a naturally occurring amino acid, is a major food-form of selenium. It has been used as a supplement, and exhibits some important functions like cancer prevention and antioxidative defense.
L-SelenoMethionine ROS inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 196.11

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Quality Control

Batch: Purity: 99.94%
99.94

Solubility

In vitro
Batch:

Water : 39 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 196.11 Formula

C5H11NO2Se

 Storage (From the date of receipt)
CAS No. 3211-76-5 Download SDF Storage of Stock Solutions

Synonyms N/A SMILES C[Se]CCC(C(=O)O)N

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Mechanism of Action

In vitro
L-SelenoMethionine (SeMet) has also been shown to contribute to the mitigation of radiation-induced oxidative stress. This compound has the ability to selectively induce apoptosis and growth arrest in cancerous, but not normal, human prostate cells. Mechanistically, its treatment is shown to promote growth inhibition in human colon cancer cells through the phosphorylation of histone H3 via the activation of MAPK extracellular regulated kinase (ERK) and subsequent phosphorylation of the ribosomal S6 kinase (RSK).
In vivo
L-SelenoMethionine (SeMet) increases survival time of NK/Ly lymphoma bearing animals treated with doxorubicin. This compound can effectively protect the hematopoietic system and liver of tumor-bearing animals with NK/Ly lymphoma from the side effects of anticancer drug doxorubicin, which is revealed by normalization of blood indexes, animal weight, and ALT/AST activity.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2020-02-05)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02644707 COMPLETED
Autoimmune Thyroiditis
Aristotle University Of Thessaloniki
 2014-08 PHASE4
NCT02302768 UNKNOWN
Thyroiditis Autoimmune
University of Siena
 2012-12 PHASE2
NCT00736164 WITHDRAWN
Prostate Cancer
Roswell Park Cancer Institute
 2008-08 PHASE2
NCT00030901 COMPLETED
Precancerous/Nonmalignant Condition; Prostate Cancer
SWOG Cancer Research Network
 2000-02 PHASE3
NCT00455416 UNKNOWN
Follicular Lymphoma
Oslo University Hospital
 2007-04 PHASE2
NCT00217516 COMPLETED
Prostate Cancer
Roswell Park Cancer Institute
 2005-03 PHASE1

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