Linalool

Catalog No.S4957 Synonyms: Phantol

For research use only.

Linalool (Phantol), a monoterpene compound commonly found as major component of essential oils of several aromatic species, is a competitive antagonist of NMDA receptors.

Linalool Chemical Structure

CAS No. 78-70-6

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Biological Activity

Description Linalool (Phantol), a monoterpene compound commonly found as major component of essential oils of several aromatic species, is a competitive antagonist of NMDA receptors.
Targets
NMDAR [2]
()
In vitro

Linalool exhibits a good cytotoxic effect on U937 and HeLa cells, with the IC50 value of 2.59 and 11.02 μM, respectively. Linalool inhibits the growth of various human cancer cells by causing apoptotic cell death. It can induce the cell cycle of U937 cells to arrest at the G0/G1 phase, while HeLa cells arrest at the G2/M phase, and its function facilitates the expression of p53, p21, p27, p16, and p18 (CDKIs) and the non-expression of CDK activity[3]. Linalool non-selectively suppresses the voltage-gated currents in newt sensory neurons and rat cerebellar Purkinje cells[4].

In vivo Linalool (i.p. 10-200mg/kg; p.o., 5-100mg/kg) shows significant antinociceptive activity against glutamate induced pain in mice, possible due mechanisms operated by ionotropic glutamate receptors, namely AMPA, NMDA and kainate but not via metabotropic receptors. Linalool (50-150mg/kg, s.c.) shows antinociceptive activity in formalin and hot-plate tests. This effect is mediated by NMDA, opioid dopamine D2, muscarinic M2 receptors and KATP channels. Linalool (50 and 100mg/kg doses) impairs long-term memory acquisition, but not short-term memory acquisition, in the object recognition task in rats[1].

Protocol (from reference)

Cell Research:

[3]

  • Cell lines: U937 cells
  • Concentrations: 1.30, 1.94, 3.24, and 6.48 μM
  • Incubation Time: 24 h
  • Method:

    Water-soluble tetrazolium salts (WST-1) analysis is used to determine inhibition of cell growth by varying the concentrations (1.30, 1.94, 3.24, and 6.48 μM) of linalool administered to U937 cells (1.2 × 105/mL) and activating for 24 h.

  • (Only for Reference)
Animal Research:

[1]

  • Animal Models: Adult male albino mice
  • Dosages: 50, 75 and 100 mg/kg
  • Administration: i.p.
  • (Only for Reference)

Chemical Information

Molecular Weight 154.25
Formula

C10H18O

Density 0.87 g/mL at 25 °C
CAS No. 78-70-6
Storage 2 years -20°C liquid
Smiles CC(=CCCC(C)(C=C)O)C

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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