Cinnamic acid

Catalog No.S3677 Synonyms: trans-Cinnamic acid, Phenylacrylic acid, Cinnamylic acid, 3-Phenylacrylic acid|(E)-Cinnamic acid, Benzenepropenoic acid, Isocinnamic acid

For research use only.

Cinnamic acid (Benzenepropenoic acid, Isocinnamic acid, trans-Cinnamic acid, Phenylacrylic acid), a naturally occurring aromatic fatty acid of low toxicity, induces cytostasis and a reversal of malignant properties of human tumor cells in vitro.

Cinnamic acid Chemical Structure

CAS No. 140-10-3

Selleck's Cinnamic acid has been cited by 1 Publication

Purity & Quality Control

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Biological Activity

Description Cinnamic acid (Benzenepropenoic acid, Isocinnamic acid, trans-Cinnamic acid, Phenylacrylic acid), a naturally occurring aromatic fatty acid of low toxicity, induces cytostasis and a reversal of malignant properties of human tumor cells in vitro.
In vitro

Cinnamic acid reduces cell proliferation of glioblastoma, melanoma, prostate and lung carcinoma cells by 50% at concentrations between 1.0 and 4.5 mM. The antiproliferative activity of the drug is associated with caspase 9 activation, but not p53 phosphorylation, after 24 h treatment. Cinnamic acid shows genotoxic potential at both tested concentrations, inducing the formation of micronucleated cells[1]. Cinnamic acid (tCA) upregulates the expression of acetyl‑H3 and acetyl‑H4 proteins in a dose-dependent manner in treated cells and in the tumor tissue of treated mice. expression of Bcl-2 (a marker of cell proliferation) is reduced, and apoptosis is induced by Cinnamic acid[2].

In vivo In vivo studies indicate that acute lethal doses (LD50) of cinnamic acid is achieved at 160-220 mg/kg (ip) in mice, 2.5 g/kg (oral) in rats and 5 g/kg (dermal) in rabbits. Thus, cinnamic acid exhibits a low toxicity[1]. Cinnamic acid could suppress the growth of colon carcinoma HT29 xenografts at well-tolerated doses[2].

Protocol (from reference)

Cell Research:[1]
  • Cell lines: HT-144
  • Concentrations: 0.0125 to 3.2 mM
  • Incubation Time: 48 h
  • Method: Briefly, 1 × 104 cells are seeded in each well containing 100 μL of DMEM plus 10% of FBS in a 96-well plate. After 24 h, various concentrations of cinnamic acid are added. The control group receives rug-free medium. After 2 days, 15 μL of "Dye Solution" are added to each well and the plates were incubated for additional 4 h. Then, 100 μL of “Solubilization/Stop Solution” are added in each well and the optical density is measured at 570 nm
  • (Only for Reference)
Animal Research:[2]
  • Animal Models: BALB/c nude mice
  • Dosages: 1.0 and 1.5 mmol/kg
  • Administration: intragastrically administered
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 29 mg/mL
(195.73 mM)
Ethanol 29 mg/mL
(195.73 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 148.16
Formula

C9H8O2

CAS No. 140-10-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC=C(C=C1)C=CC(=O)O

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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