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Cinnamic acid

Cat.No.S3677

Cinnamic acid (Benzenepropenoic acid, Isocinnamic acid, trans-Cinnamic acid, Phenylacrylic acid), a naturally occurring aromatic fatty acid of low toxicity, induces cytostasis and a reversal of malignant properties of human tumor cells in vitro.
Cinnamic acid Chemical Structure

Chemical Structure

Molecular Weight: 148.16

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Quality Control

Batch: S367701 DMSO]29 mg/mL]false]Ethanol]29 mg/mL]false]Water]Insoluble]false Purity: 99.98%
99.98

Solubility

In vitro
Batch:

DMSO : 29 mg/mL (195.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 29 mg/mL

Water : Insoluble

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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%
% Tween 80
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 148.16 Formula

C9H8O2

 Storage (From the date of receipt)
CAS No. 140-10-3 Download SDF Storage of Stock Solutions

Synonyms trans-Cinnamic acid, Phenylacrylic acid, Cinnamylic acid, 3-Phenylacrylic acid|(E)-Cinnamic acid, Benzenepropenoic acid, Isocinnamic acid Smiles C1=CC=C(C=C1)C=CC(=O)O

Mechanism of Action

In vitro
Cinnamic acid reduces cell proliferation of glioblastoma, melanoma, prostate and lung carcinoma cells by 50% at concentrations between 1.0 and 4.5 mM. The antiproliferative activity of the drug is associated with caspase 9 activation, but not p53 phosphorylation, after 24 h treatment. This compound shows genotoxic potential at both tested concentrations, inducing the formation of micronucleated cells. It upregulates the expression of acetyl‑H3 and acetyl‑H4 proteins in a dose-dependent manner in treated cells and in the tumor tissue of treated mice. Expression of Bcl-2 (a marker of cell proliferation) is reduced, and apoptosis is induced by this chemical.
In vivo
In vivo studies indicate that acute lethal doses (LD50) of cinnamic acid is achieved at 160-220 mg/kg (ip) in mice, 2.5 g/kg (oral) in rats and 5 g/kg (dermal) in rabbits. Thus, this compound exhibits a low toxicity. It could suppress the growth of colon carcinoma HT29 xenografts at well-tolerated doses.
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