Home Neuronal Signaling Beta Amyloid chemical (-)-epigallocatechin

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(-)-epigallocatechin Beta Amyloid chemical

Cat.No.S3922

(-)-Epigallocatechin, widespread in plants, has been shown to exhibit anti-tumor, anti-cancer and anti-inflammatory functions.
(-)-epigallocatechin Beta Amyloid chemical Chemical Structure

Chemical Structure

Molecular Weight: 306.27

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Quality Control

Batch: S392201 DMSO]61 mg/mL]false]]]false]]]false Purity: 99.38%
99.38

Solubility

In vitro
Batch:

DMSO : 61 mg/mL (199.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 306.27 Formula

C15H14O7

 Storage (From the date of receipt)
CAS No. 970-74-1 -- Storage of Stock Solutions

Synonyms N/A SMILES C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)O

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Mechanism of Action

In vitro
(-)-Epigallocatechin (EGC) shows the anti-proliferation effects on AML cells. EGC-treated cells show not only the suppression of FLT3, but also the suppression of phosphorylation of MAPK, AKT and STAT5. EGC suppresses FLT3 expression through Hsp90. EGC inhibits heregulin-β1 (HRG)-induced migration/invasion of MCF-7 human breast carcinoma cells. It does not cause modification of MCF-7 cell cycle phases. EGC inhibits HRG-induced phosphorylation of ErbB2/ErbB3 at a low cell confluence and does not activate Akt at either a low or high cell confluence.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-06-26)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
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Frailty; Inflammation
University of Rochester
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NCT06015022 RECRUITING
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University of Texas Southwestern Medical Center
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NCT07697196 NOT_YET_RECRUITING
HPV Infection; HPV Integration; HPV Disease; HPV Genital Infection; HPV Persistence; Low Grade Squamous Intraepithelial Lesions of the Cervix
IRCCS San Raffaele
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NCT07149506 ENROLLING_BY_INVITATION
Radiation Dermatitis Acute; Radiation Dermatitis; Fibrosis; Skin
CARLOS FRANCISCO SAAVEDRA GARCIA
 2025-09-01 PHASE3
NCT05364008 ACTIVE_NOT_RECRUITING
Leiomyoma, Uterine
Yale University
 2023-01-05 PHASE3
NCT05409872 COMPLETED
Leiomyoma, Uterine
Universita di Verona
 2022-09-15

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