(-)-epigallocatechin

Catalog No.S3922

For research use only.

(-)-Epigallocatechin, widespread in plants, has been shown to exhibit anti-tumor, anti-cancer and anti-inflammatory functions.

(-)-epigallocatechin Chemical Structure

CAS No. 970-74-1

Selleck's (-)-epigallocatechin has been cited by 2 Publications

Purity & Quality Control

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Biological Activity

Description (-)-Epigallocatechin, widespread in plants, has been shown to exhibit anti-tumor, anti-cancer and anti-inflammatory functions.
In vitro

(-)-Epigallocatechin (EGC) shows the anti-proliferation effects on AML cells. EGC-treated cells show not only the suppression of FLT3, but also the suppression of phosphorylation of MAPK, AKT and STAT5. EGC suppresses FLT3 expression through Hsp90[1]. EGC inhibits heregulin-β1 (HRG)-induced migration/invasion of MCF-7 human breast carcinoma cells. It does not cause modification of MCF-7 cell cycle phases. EGC inhibits HRG-induced phosphorylation of ErbB2/ErbB3 at a low cell confluence and does not activate Akt at either a low or high cell confluence[2].

Protocol (from reference)

Cell Research:[1]
  • Cell lines: MOLM-13, MOLM-14, MV4-11 and KOCL-48 cells
  • Concentrations: 0-200 μM
  • Incubation Time: 72 h
  • Method: Cell proliferation is determined by trypan blue dye exclusion test. Briefly, cells are seeded in 6-well plates at a density of 1×105 cells/ml in the presence of different concentrations of EGCG, EGC, ECG and C for 72 hours. After the treatment, 10 µl of the cell suspension is mixed with 10 µl of 0.4% trypan blue, and alive cells are counted manually using a hemacytometer.
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 61 mg/mL
(199.17 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 306.27
Formula

C15H14O7

CAS No. 970-74-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)O

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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