(-)-epigallocatechin

For research use only.

Catalog No.S3922

2 publications

(-)-epigallocatechin Chemical Structure

CAS No. 970-74-1

(-)-Epigallocatechin, widespread in plants, has been shown to exhibit anti-tumor, anti-cancer and anti-inflammatory functions.

Selleck's (-)-epigallocatechin has been cited by 2 publications

Purity & Quality Control

Biological Activity

Description (-)-Epigallocatechin, widespread in plants, has been shown to exhibit anti-tumor, anti-cancer and anti-inflammatory functions.
In vitro

(-)-Epigallocatechin (EGC) shows the anti-proliferation effects on AML cells. EGC-treated cells show not only the suppression of FLT3, but also the suppression of phosphorylation of MAPK, AKT and STAT5. EGC suppresses FLT3 expression through Hsp90[1]. EGC inhibits heregulin-β1 (HRG)-induced migration/invasion of MCF-7 human breast carcinoma cells. It does not cause modification of MCF-7 cell cycle phases. EGC inhibits HRG-induced phosphorylation of ErbB2/ErbB3 at a low cell confluence and does not activate Akt at either a low or high cell confluence[2].

Protocol

Cell Research:[1]
- Collapse
  • Cell lines: MOLM-13, MOLM-14, MV4-11 and KOCL-48 cells
  • Concentrations: 0-200 μM
  • Incubation Time: 72 h
  • Method: Cell proliferation is determined by trypan blue dye exclusion test. Briefly, cells are seeded in 6-well plates at a density of 1×105 cells/ml in the presence of different concentrations of EGCG, EGC, ECG and C for 72 hours. After the treatment, 10 µl of the cell suspension is mixed with 10 µl of 0.4% trypan blue, and alive cells are counted manually using a hemacytometer.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 61 mg/mL (199.17 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 306.27
Formula

C15H14O7

CAS No. 970-74-1
Storage powder
in solvent
Synonyms N/A
Smiles C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Related Others Products

Tags: buy (-)-epigallocatechin | (-)-epigallocatechin supplier | purchase (-)-epigallocatechin | (-)-epigallocatechin cost | (-)-epigallocatechin manufacturer | order (-)-epigallocatechin | (-)-epigallocatechin distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID