Rheic Acid

Catalog No.S2400 Synonyms: Rhein, Monorhein, NSC 38629, Rheinic Acid

For research use only.

Rhein (Monorhein, NSC 38629, Rheinic) is an anthraquinone compound enriched in the fresh rhizome of Rheum coreanum Nakai, showing anti-inflammation and antitumor activities. Rhein is an FTO (mRNA N6-methyladenine demethylase) inhibitor and also inhibits AlkB repair enzymes.

Rheic Acid Chemical Structure

CAS No. 478-43-3

Selleck's Rheic Acid has been cited by 1 Publication

Purity & Quality Control

Choose Selective FTO Inhibitors

Biological Activity

Description Rhein (Monorhein, NSC 38629, Rheinic) is an anthraquinone compound enriched in the fresh rhizome of Rheum coreanum Nakai, showing anti-inflammation and antitumor activities. Rhein is an FTO (mRNA N6-methyladenine demethylase) inhibitor and also inhibits AlkB repair enzymes.
In vitro

Rhein at 35 μM can effectively inhibit the synthesis of IL-1β on human osteoarthritis synovium, as well as the action of this cytokine at the cartilage level, by reducing the number of chondrocyte IL-1R and inhibiting IL-1β induced NO production in chondrocytes and cartilage. [1] [2] Rhein also induces apoptosis in human promyelocytic leukemia cells (HL-60), characterized by caspase activation, poly(ADP)ribose polymerase (PARP) cleavage, and DNA fragmentation. [3]

In vivo Rhein is also effective in ameliorating diabetic renal pathological changes and attenuating hyperlipidemia in db/db mice with diabetic nephropathy with decreased transforming growth factor-beta1 (TGF-beta1) and fibronectin immunohistochemistry expression in renal tissue and reduced cholesterol (Chol), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and ApoE in plasma. [4]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO Insoluble
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 284.22
Formula

C15H8O6

CAS No. 478-43-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)C(=O)O

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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