4'-Methoxyresveratrol

For research use only.

Catalog No.S3939

4'-Methoxyresveratrol Chemical Structure

CAS No. 33626-08-3

4-Methoxyresveratrol is a stibenoid found in the Chinese herb Gnetum cleistostachyum. 4'-Methoxyresveratrol alleviates AGE-induced inflammation through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation.

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Biological Activity

Description 4-Methoxyresveratrol is a stibenoid found in the Chinese herb Gnetum cleistostachyum. 4'-Methoxyresveratrol alleviates AGE-induced inflammation through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation.
Targets
NF-κB [1]
()
NLRP3 [1]
()

Protocol

Solubility (25°C)

In vitro DMSO 48 mg/mL (198.12 mM)
Ethanol 48 mg/mL (198.12 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 242.27
Formula

C15H14O3

CAS No. 33626-08-3
Storage powder
in solvent
Synonyms N/A
Smiles COC1=CC=C(C=C1)C=CC2=CC(=CC(=C2)O)O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01199250 Not yet recruiting Other: Laboratory Biomarker Analysis Lynch Syndrome|Recurrent Uterine Corpus Carcinoma|Stage I Uterine Corpus Cancer|Stage II Uterine Corpus Cancer|Stage III Uterine Corpus Cancer|Stage IV Uterine Corpus Cancer Gynecologic Oncology Group|National Cancer Institute (NCI) January 2100 --
NCT02442752 Withdrawn Drug: Dexlansoprazole Pediatric Gastroesophageal Reflux Disease Takeda June 15 2025 Phase 1
NCT03643887 Not yet recruiting Drug: FMT Capsule DE|Drug: Placebo oral capsule Clostridium Difficile Infection University of Wisconsin Madison September 1 2022 Phase 2
NCT03737617 Suspended Drug: Cuvitru 20 % Injectable Solution Bronchiectasis|Immunoglobulin Subclass Deficiency University of Edinburgh|NHS Lothian August 5 2022 Phase 4
NCT04431193 Not yet recruiting Drug: Oxytocin Osteoarthritis Knee Wake Forest University Health Sciences July 2022 Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID