Home Metabolism Phospholipase (e.g. PLA) activator Melittin

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Melittin Phospholipase (e.g. PLA) activator

Cat.No.S9794

Melittin (MLT, Forapin, Forapine) is an activator of phospholipase A2 (PLA2) that stimulates the activity of the low molecular weight PLA2, while it does not the increase the activity of the high molecular weight enzyme.
Melittin Phospholipase (e.g. PLA) activator Chemical Structure

Chemical Structure

Molecular Weight: 2846.46

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Quality Control

Batch: S979401 Water]100 mg/mL]false]]]false]]]false Purity: 99.79%
99.79

Solubility

In vitro
Batch:

Water : 100 mg/mL

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 2846.46 Formula

C131H229N39O31

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 20449-79-0, 37231-28-0 -- Storage of Stock Solutions

Synonyms MLT, Forapin, Forapine Smiles CCC(C)C(NC(=O)CN)C(=O)NCC(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(C(C)O)C(=O)NC(C(C)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(C)C(=O)NC(CC(C)C)C(=O)NC(C(C)CC)C(=O)NC(CO)C(=O)NC(CC2=C[NH]C3=C2C=CC=C3)C(=O)C(=O)C(NC(=O)C(CCCCN)NNC(CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCC(N)=O)C(=O)NC(CCC(N)=O)C(N)=O)C(C)CC

Mechanism of Action

Targets/IC50/Ki
PLA2
In vitro

In vitro studies using TNF-α/IFN-γ-stimulated human keratinocytes shows that melittin inhibits the increased expression of chemokines, such as CCL17 and CCL22, and pro-inflammatory cytokines, including IL-1β, IL-6 and IFN-γ, through the blockade of the NF‐κB and STAT signalling pathways.
In vivo

Melittin exhibits potent anti-atopic activities, shown by decreased Atopic dermatitis (AD)-like skin lesions, induced by DNCB in mice.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05617833 Recruiting
Intraventricular Hemorrhage of Prematurity
Johns Hopkins University|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
 April 15 2024 Phase 1
NCT05827575 Recruiting
Functional Dyspepsia|Sleep Disturbances
Second Affiliated Hospital of Xi''an Jiaotong University
 March 30 2022 Not Applicable
NCT02537431 Completed
X-linked Hypophosphatemia
Kyowa Kirin Inc.|Kyowa Kirin Co. Ltd.
 December 23 2015 Phase 3

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