Catalog No.S4714 Synonyms: L-Menthol|Levomenthol|Menthomenthol|Menthacamphor
Molecular Weight(MW): 156.27
(-)-Menthol is a levo isomer of menthol and used as a cooling agent that strongly activates TRPM8.
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|Description||(-)-Menthol is a levo isomer of menthol and used as a cooling agent that strongly activates TRPM8.|
(-)-Menthol induces cytotoxicity against murine leukemia WEHI-3 cells in vitro in a dosedependent manner. (-)-Menthol inhibits the growth of rat liver epithelial tumor cells and acts as a potent chemopreventive agent during DMBA initiation of rat mammary tumors. (-)-menthol inhibits N-acetyltransferase activity. It also is found to inhibit the DNA topoisomerase I, II alpha and beta and to promote NF-kappaB expression in human gastric cancer SNU-5 cells. Additionally, (-)-menthol induces human promyelocytic leukemia HL-60 cell death through the Ca2+ release from the endoplasmic reticulum.
|In vivo||The effects of (-)-menthol on WEHI-3 cells in vivo (BALB/c mice) were also examined, and it was observed that the Mac-3 and CD11b markers were decreased, indicating inhibition of differentiation of the precursor of macrophage and granulocyte. The weights of liver and spleen samples from mice treated with (-)-menthol were found to be decreased compared to untreated animals. (-)-Menthol has been shown to be toxic in animals, but in humans, it is considered to be safe, with a small cardio-accelerating effect. At high doses (-)-menthol may exert a depressant effect on the central nervous system in rodents. (-)-menthol statistically decreases the weights of the liver and spleen in the examined animals and also decreases the percentage of MAC-3 and CD11b cells in the blood..|
|In vitro||DMSO||31 mg/mL (198.37 mM)|
|Ethanol||31 mg/mL (198.37 mM)|
|Water||16 mg/mL (102.38 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03132142||Recruiting||Pain|Pruritus|Neuropathic Pain|Dermatology/Skin - Other||Aalborg University||April 2017||Not Applicable|
|NCT02653703||Completed||Inflammation|Pruritus|Hyperalgesia||Aalborg University||October 2014||Not Applicable|
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