Home PI3K/Akt/mTOR Akt inhibitor Usnic acid

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Usnic acid Akt inhibitor

Cat.No.S4953

Usnic acid (Usniacin) is a furandione found uniquely in lichen that is used widely in cosmetics, deodorants, toothpaste and medicinal creams as well as some herbal products. It exhibits antiviral, antiprotozoal, antiproliferative, anti-inflammatory and analgesic activity. This compound inhibits breast tumor angiogenesis and growth by suppressing VEGFR2-mediated AKT and ERK1/2 signaling pathways.
Usnic acid Akt inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 344.32

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Quality Control

Batch: S495301 DMSO]4 mg/mL]false]]]false]]]false Purity: 99.89%
99.89

Solubility

In vitro
Batch:

DMSO : 4 mg/mL (11.61 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Chemical Information, Storage & Stability

Molecular Weight 344.32 Formula

C18H16O7

 Storage (From the date of receipt)
CAS No. 125-46-2 -- Storage of Stock Solutions

Synonyms Usniacin Smiles CC1=C(C(=C2C(=C1O)C3(C(=CC(=O)C(C3=O)C(=O)C)O2)C)C(=O)C)O

Mechanism of Action

Targets/IC50/Ki
Akt
ERK
In vitro

Usnic acid inhibits cell growth involving G0/G1 phase cell cycle arrest and induces cell death via mitochondrial membrane depolarization and induction of apoptosis in human lung carcinoma cells. This compound has shown activity againstmany cancer cells such as lung carcinoma cells, murine leukemia P388 and L1210 cells, colon carcinoma HT-29 and HCT-116 cells, breast adenocarcinoma MCF-7 cells, and cervix adenocarcinoma cells. It also selectively inhibits the viability of human breast cancer MCF-7 cells in a concentration- and time-dependent manner, provoking the generation of reactive oxygen species (ROS), which triggers the mitochondrial/caspase apoptotic pathway in MCF-7 cells.
In vivo

In an MCF-7 xenograft model, Usnic acid significantly suppresses the growth of tumors by inducing apoptosis in the tumor cells without overt toxic side effects.
References

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