Glucosamine sulfate

Name: Glucosamine sulfate
Brand: Selleck Chemicals
SKU: S3850
Rating: 5 (1 reviews)

Synonyms: D-Glucosaminesulfate, D-Glucosamine sulphate

Catalog No.S3850 Purity: 98%

Glucosamine sulfate (D-Glucosaminesulfate, D-Glucosamine sulphate) is a dietary supplement commonly used in the treatment of osteoarthritis. It is a type of glycosaminoglycan, which is a naturally occurring major component of joint cartilage and joint fluid.

Glucosamine sulfate Chemical Structure

CAS: 29031-19-4

Purity & Quality Control

Batch: S385001 Water] 55 mg/mL] false] DMSO] 4 mg/mL] false] ] ] false Purity: 98%

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Biological Activity

Description	Glucosamine sulfate (D-Glucosaminesulfate, D-Glucosamine sulphate) is a dietary supplement commonly used in the treatment of osteoarthritis. It is a type of glycosaminoglycan, which is a naturally occurring major component of joint cartilage and joint fluid.

In vitro
In vitro	Glucosamine sulfate exerts a pronounced suppressive effect on MMPs in osteosarcoma cell lines in vitro^[1]. Glucosamine suppresses the activation of T-lymphoblasts and dendritic cells in vitro as well as allogeneic mixed leukocyte reactivity in a dose-dependent manner. Glucosamine has been shown to inhibit nucleic acid and protein biosynthesis and irreversible damage to organelles in tumor cells, but not in normal cells^[3].
Cell Research	Cell lines	MG-63 and SaOS-2 cells
	Concentrations	0, 10, 50 and 100 μg/ml
	Incubation Time	48 h
	Method	Cells are exposed to 0, 10, 50 and 100 μg/ml glucosamine sulfate for 48 h and treatment toxicity is determined through measurement of cell viability and proliferation. Relative gene expression of matrix metalloproteinase (MMP)-2, -3 and -9 is quantified by real-time polymerase chain reaction. Protein levels of MMP-2 and -9 are assessed by ELISA.

In Vivo
In vivo	Glucosamine sulfate attenuates DSS-induced colitis symptoms, possibly by suppressing the NF-κB-mediated TNF-α and IL-1β production and neutrophil activation that contribute to intestinal barrier disruption in colitic mice^[2]. Glucosamine administration prolongs allogeneic cardiac allograft survival in vivo^[3].
Animal Research	Animal Models	C57BL/6 mice
	Dosages	0, 0.05, and 0.10% (w/w)
	Administration	oral

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT03827161	Completed	Healthy Subject\|Overweight	Fred Hutchinson Cancer Center	August 1 2017	Phase 1

References

Chemical Information & Solubility

Molecular Weight	277.25	Formula	C₆H₁₃NO₅.H₂SO₄
CAS No.	29031-19-4	SDF	--
Smiles	C(C(C(C(C(C=O)N)O)O)O)O.OS(=O)(=O)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

Water : 55 mg/mL

DMSO : 4 mg/mL ( (14.42 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

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In vivo
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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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