Home Metabolism Amino Acids and Derivatives chemical isoleucine

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isoleucine Amino Acids and Derivatives chemical

Cat.No.S3752

Isoleucine (Ile) is a non-polar, uncharged (at physiological pH), aliphatic amino acid that is used in the biosynthesis of proteins.
isoleucine Amino Acids and Derivatives chemical Chemical Structure

Chemical Structure

Molecular Weight: 131.17

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Quality Control

Batch: S375201 Water]26 mg/mL]false]DMSO]Insoluble]false]]]false Purity: 98%
98

Solubility

In vitro
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Water : 26 mg/mL

DMSO : Insoluble
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Chemical Information, Storage & Stability

Molecular Weight 131.17 Formula

C6H13NO2

 Storage (From the date of receipt)
CAS No. 73-32-5 Download SDF Download SDF Storage of Stock Solutions

Mechanism of Action

In vitro
Isoleucine plays a major role in enhancing glucose consumption and utilization by up-regulating intestinal and muscular glucose transporters. This compound could induce β-defensins’expressions in porcine intestinal epithelial cells.
In vivo
Isoleucine is beneficial for mammary health, milk quality and embryo growth, enhances intestinal development, intestinal amino acid transportation and mucin production and participates in up-regulating innate and adaptive immune responses. Studies in mice have indicated that diet-induced obesity mice in this compound treatment (final concentration of 2.5% isoleucine in drinking water) had almost 6% lower body weight gain and 49% less epididymal white adipose tissue mass compared with the control treatment, with higher levels of hepatic protein. Its deprivation induces fat mass loss in mice. This chemical could stimulate glucose uptake and participated in plasma glucose uptake in the rat.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06365268 Not yet recruiting
Perinatal Solid Tumors of the Thoraco-abdomino-pelvic Region
Assistance Publique - Hôpitaux de Paris
 May 2024 --
NCT06142513 Not yet recruiting
Obesity Hypoventilation Syndrome|Obesity|Hypoventilation|Respiration Disorders|Sleep Disorder; Breathing-Related
Istanbul University|Istanbul University - Cerrahpasa (IUC)
 April 10 2024 --
NCT05026047 Not yet recruiting
Papillomavirus Infection
Assistance Publique - Hôpitaux de Paris
 May 2023 Not Applicable
NCT05812144 Recruiting
Type 1 Facioscapulohumeral Muscular Dystrophy
Centre Hospitalier Universitaire de Nice
 May 23 2023 Not Applicable

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