Taurochenodeoxycholic acid

For research use only.

Catalog No.S3865 Synonyms: Taurochenodeoxycholate, TCDCA, 12-Deoxycholyltaurine, Chenodeoxycholyltaurine, Chenyltaurine

1 publication

Taurochenodeoxycholic acid Chemical Structure

CAS No. 516-35-8

Taurochenodeoxycholic acid (Taurochenodeoxycholate, TCDCA, Chenodeoxycholyltaurine), a bile acid formed in the liver of most species, is used as a cholagogue and choleretic.

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Selleck's Taurochenodeoxycholic acid has been cited by 1 publication

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Biological Activity

Description Taurochenodeoxycholic acid (Taurochenodeoxycholate, TCDCA, Chenodeoxycholyltaurine), a bile acid formed in the liver of most species, is used as a cholagogue and choleretic.
In vitro

Taurochenodeoxycholic acid (TUDCA) induces dissociation of CD34+ HSCs from stromal cells by decreasing adhesion molecule expression. It induces bone marrow stem cell mobilization and differentiation into endothelial progenitor cells (EPCs) and enhances EPC proliferation, invasion, and tube formation via Akt and ERK activation[1]. TCDCA induces the apoptosis process through the activation of caspase cascade in macrophages, and this process may be involved in PKC/JNK signaling pathway[2].

In vivo TUDCA has neuroprotective effects in neuronal cultures and positive effects on ischemia reperfusion in animal models, reducing infarct area and inflammation via attenuation of endoplasmic reticulum (ER) stress. TUDCA is incorporated into target cells via organic anion transporter (OATP) 2, OATP8, and the Na+‐taurocholate cotransporting polypeptide (NTCP). TUDCA inhibits neointimal hyperplasia by promoting apoptosis of smooth muscle cells via induction of MAP kinase phosphatase‐1 (MKP‐1) expression. In addition, TUDCA protects the hepatocytes and restores glucose homeostasis by reducing ER stress. TUDCA enhances neovascularization in vivo[1]. TCDCA in dosages of 0.05 and 0.1g/kg can extremely significantly decrease the pulmonary coefficient in the model mice. TCDCA in a dosage of 0.2g/kg significantly decreases the pulmonary coefficient in the model mice (P<0.05); TCDCA in dosages of 0.05 and 0.1g/kg significantly reduce the pathological damages on their lungs; TCDCA can extremely significantly decrease the expression levels of TNF-α and TIMP-2 in pulmonary tissues in the pulmonary fibrosis mice (P>0.01), the expression level of MMP-9 extremely significantly increased (P>0.01), while it has no significant effects on MMP2. Thus, TCDCA has antagonistic actions on pulmonary fibrosis in mice[3].

Protocol

Cell Research:[1]
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  • Cell lines: CD34+ HSCs
  • Concentrations: 50 and 100 μM
  • Incubation Time: 5 h
  • Method: --
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: C57BL/6 mice
  • Dosages: 20 mg/kg
  • Administration: oral adminitration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 99 mg/mL (198.11 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 499.70
Formula

C26H45NO6S

CAS No. 516-35-8
Storage powder
in solvent
Synonyms Taurochenodeoxycholate, TCDCA, 12-Deoxycholyltaurine, Chenodeoxycholyltaurine, Chenyltaurine
Smiles CC(CCC(=O)NCCS(=O)(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID