Ammonium Glycyrrhizinate

Catalog No.S2376 Synonyms: AMGZ, Glycyram, Glycyrrhizin ammonium salt, Glycyrrhizic acid ammonium salt

For research use only.

Ammonium Glycyrrhizinate (AMGZ, Glycyram, Glycyrrhizin ammonium salt, Glycyrrhizic acid ammonium salt) is a unique product from Licorice root with a very high sweetness. Ammonium glycyrrhizinate is a direct inhibitor of HMGB1 with anti-inflammatory, anti-tumor, anti-diabetic activities. Ammonium Glycyrrhizinate inhibits growth and cytopathology of several unrelated DNA and RNA viruses. Ammonium Glycyrrhizinate also inhibits both hepatic delta 4-5-reductase and 11 beta-hydroxysteroid dehydrogenase.

Ammonium Glycyrrhizinate Chemical Structure

CAS No. 1407-03-0

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Biological Activity

Description Ammonium Glycyrrhizinate (AMGZ, Glycyram, Glycyrrhizin ammonium salt, Glycyrrhizic acid ammonium salt) is a unique product from Licorice root with a very high sweetness. Ammonium glycyrrhizinate is a direct inhibitor of HMGB1 with anti-inflammatory, anti-tumor, anti-diabetic activities. Ammonium Glycyrrhizinate inhibits growth and cytopathology of several unrelated DNA and RNA viruses. Ammonium Glycyrrhizinate also inhibits both hepatic delta 4-5-reductase and 11 beta-hydroxysteroid dehydrogenase.
Targets
11-beta-hydroxysteroid dehydrogenases [1]
In vitro

Ammonium glycyrrhizinate (AG) prepared from glycyrrhizin dramatically protects AGS cells from H(2)O(2)-induced damage as measured by the integrity of actin cytoskeleton. AG also inhibits FeSO(4)-induced reactive oxygen radicals in a dose-dependent manner, suggesting the role for AG as a free radical scavenger. [1]

In vivo Ammonium glycyrrhizinate (28 mg/kg) leads to changes in the activity of some enzymes in the brain, the development of parenchymatous dystrophy of the liver which changed to acidophilic necrosis attended with signs of regeneration in mice and rats model. [2] Ammonium glycyrrhizinate-loaded nonionic surfactant vesicles (NSVs) decreases edema and nociceptive responses when compared with Ammonium glycyrrhizinate alone and empty NSVs in mice model. [3] Ammonium glycyrrhizinate up-regulates interleukin-10 (IL-10) level and down-regulates the tumor neurosis factor-α (TNF-α) level and inhibits the cyclic adenosine monophosphate-phosphodiesterase (cAMP-PDE) activity in the lung tissue of mice. Ammonium glycyrrhizinate -loaded non-ionic surfactant vesicles shows no toxicity, good skin tolerability and are able to improve the drug anti-inflammatory activity in mice. [4] Ammonium glycyrrhizinate significantly decreases triglyceride, cholesterol, low density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels in rats. Ammonium glycyrrhizinate increases high density lipoprotein (HDL) levels increased in rats. [5]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 839.96
Formula

C42H62O16.NH3

CAS No. 1407-03-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1(C2CCC3(C(C2(CCC1OC4C(C(C(C(O4)C(=O)O)O)O)OC5C(C(C(C(O5)C(=O)O)O)O)O)C)C(=O)C=C6C3(CCC7(C6CC(CC7)(C)C(=O)O)C)C)C)C.N

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02939144 Completed Dietary Supplement: Liquorice Apparent Mineralocorticoid Excess The Royal Wolverhampton Hospitals NHS Trust November 2016 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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