Gallic acid

Catalog No.S4603 Synonyms: 3,4,5-Trihydroxybenzoic acid, Gallate, Benzoic acid

Gallic acid Chemical Structure

Molecular Weight(MW): 170.12

Gallic acid, known as powerful antioxidants, is an organic acid found in a variety of foods and herbs.

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Biological Activity

Description Gallic acid, known as powerful antioxidants, is an organic acid found in a variety of foods and herbs.
In vitro

Gallic acid does not protect against H(2)O(2)-induced PC12 cell death. It reduced the viability of PC12 cells in a dose-dependent manner. Gallic acid also induces cleavage of poly (ADP-ribose) polymerase, which is strongly related to apoptosis in neurons. Gallic acid induces the phosphorylation of c-Jun N-terminal protein kinase (JNK) and the downregulation of Bcl-2 in PC12 cells. Gallic acid leads to a progressive reduction in the viability of vector-transfected PC12 cells, which is delayed in PC12 cells that overexpressed Bcl-2[2].

In vivo Gallic acid effectively protects rat erythrocytes. The antioxidant effect of the compound at the tested dosage in vivo was more prevalent than its prooxidative effects. Gallic acid has ameliorative effect on lipid peroxidation in vivo[1].


Cell Research:[2]
+ Expand
  • Cell lines: PC12 cells
  • Concentrations: 25 or 50 μM
  • Incubation Time: 24 h
  • Method: Cell viability is measured using the MTT assay. PC12 cells are incubated at 37◦C with H2O2 or gallic acid at different concentrations for 24 h with or without pretreatment with resveratrol. They are then treated with the MTT solution (final concentration, 1 mg/mL) for 2 h. The dark-blue formazan crystals that formed in intact cells are dissolved in DMSO, and the absorbance at 570 nm is measured using a micro-ELISA reader.
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Male Wistar rats
  • Formulation: isotonic saline solution
  • Dosages: 10 mg/kg and 20 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 34 mg/mL (199.85 mM)
Ethanol 34 mg/mL (199.85 mM)
Water 7 mg/mL (41.14 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 170.12


CAS No. 149-91-7
Storage powder
in solvent
Synonyms 3,4,5-Trihydroxybenzoic acid, Gallate, Benzoic acid

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03740295 Recruiting Multiple Sclerosis Fundación Universidad Católica de Valencia San Vicente Mártir October 5 2018 Phase 2
NCT03190785 Recruiting Obesity|Metabolic Syndrome East Carolina University July 1 2017 Not Applicable
NCT02891538 Recruiting Colon Cancer The University of Texas Health Science Center at San Antonio January 31 2017 Early Phase 1
NCT03194620 Completed Healthy University of California Davis|Mars Inc. August 2016 Not Applicable
NCT03199430 Completed EGCG Influence on Catecholamine Metabolism Swansea University September 2015 Phase 4
NCT02558933 Unknown status Fetal Alcohol Syndrome (FAS) Parc de Salut Mar|Fundación Mutua Madrileña June 2015 Phase 2|Phase 3

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID