Name: Gallic acid
Brand: Selleck Chemicals
SKU: S4603
Availability: InStock
Rating: 5 (6 reviews)

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Quality Control

Batch: Purity: 99.94%

99.94

Related Targets	PD-1/PD-L1 CXCR STING AhR Immunology & Inflammation related CD markers Interleukins Anti-infection Antioxidant COX
Other ROS Inhibitors	Piperlongumine MitoQ (Mitoquinone) Mesylate H2DCFDA (DCFH-DA) Neohesperidin Carnosic acid (20R)Ginsenoside Rg3 Pyrogallol Idebenone Asiaticoside Sarsasapogenin

Solubility

In vitro
Batch:

DMSO : 34 mg/mL (199.85 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 34 mg/mL

Water : 7 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	1.700mg/ml (9.99mM)	Taking the 1 mL working solution as an example, add 50 μL of 34 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.340mg/ml (2.00mM)	Taking the 1 mL working solution as an example, add 50 μL of 6.8 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	170.12	Formula	C₇H₆O₅	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	149-91-7	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	3,4,5-Trihydroxybenzoic acid, Gallate, Benzoic acid			Smiles	C1=C(C=C(C(=C1O)O)O)C(=O)O

Mechanism of Action

In vitro	Gallic acid does not protect against H(2)O(2)-induced PC12 cell death. It reduced the viability of PC12 cells in a dose-dependent manner. This compound also induces cleavage of poly (ADP-ribose) polymerase, which is strongly related to apoptosis in neurons. It induces the phosphorylation of c-Jun N-terminal protein kinase (JNK) and the downregulation of Bcl-2 in PC12 cells. This chemical leads to a progressive reduction in the viability of vector-transfected PC12 cells, which is delayed in PC12 cells that overexpressed Bcl-2.
In vivo	Gallic acid effectively protects rat erythrocytes. The antioxidant effect of this compound at the tested dosage in vivo was more prevalent than its prooxidative effects. It has ameliorative effect on lipid peroxidation in vivo.
References	[1] https://pubmed.ncbi.nlm.nih.gov/24384762/ [2] https://pubmed.ncbi.nlm.nih.gov/19723098/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT03413735	Unknown status	Obesity\|Endotoxemia\|Inflammation	Ohio State University	August 29 2018	Not Applicable
NCT02779361	Completed	Healthy Volunteers\|Doping in Sports	Parc de Salut Mar\|World Anti-Doping Agency	January 2016	Phase 1
NCT02008721	Completed	Multiple System Atrophy	Dr. Johannes Levin\|German Center for Neurodegenerative Diseases (DZNE)\|Deutsche Parkinson Vereinigung\|German Foundation for Neurology\|ParkinsonFonds Deutschland gGmbH\|Ludwig-Maximilians - University of Munich	January 2014	Phase 3

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Gallic acid ROS inhibitor

Chemical Structure

Molecular Weight: 170.12