Home Neuronal Signaling BACE inhibitor - AChR inhibitor - BChE inhibitor Loganin

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Loganin BACE inhibitor

Cat.No.S3835

Loganin (Loganoside) is an iridoid glycoside first isolated from the seeds of Strychnos nux-vomica, a member of the Loganiaceae family. This compound is a non-competitive inhibitor of BACE1 with IC50 of 47.97 μM an also inhibits AChE and BChE with IC50 values of 3.95 μM and 33.02 μM, respectively.
Loganin BACE inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 390.38

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Quality Control

Batch: S383501 DMSO]78 mg/mL]false]]]false]]]false Purity: 99.94%
99.94

Chemical Information, Storage & Stability

Molecular Weight 390.38 Formula

C17H26O10

 Storage (From the date of receipt)
CAS No. 18524-94-2 Download SDF Storage of Stock Solutions

Synonyms Loganoside Smiles CC1C(CC2C1C(OC=C2C(=O)OC)OC3C(C(C(C(O3)CO)O)O)O)O

Solubility

In vitro
Batch:

DMSO : 78 mg/mL ( (199.8 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

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Mass Concentration Volume Molecular Weight

In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Mechanism of Action

Targets/IC50/Ki
AChE [1]
(Cell-free assay)
3.95 μM
BChE [1]
(Cell-free assay)
33.02 μM
BACE1 [1]
(Cell-free assay)
47.97 μM
In vitro
In SMN-deficient NSC34 cells, loganin increases cell viability, neurite length, and expressions of SMN, Gemin2, SMN-Gemin2 complex, p-Akt, p-GSK-3, p-CREB, BDNF and Bcl-2. This compound attenuates H2O2-induced neuronal damage via suppressing MAPKs signals in SH-SY5Y cells[2]. It may directly promote the differentiation and inhibit the apoptosis of MC3T3-E1 cells and indirectly reduce bone resorption. This chemical could directly enhance the function of osteoblasts and elevate their survival rate, indirectly inhibit the function of osteoclastd and reduce the number of osteoclastd via RANKL from osteoblastd[3].
In vivo
Loganin provides benefits to SMA (pinal muscular atrophy) therapeutics via improving SMN (survival motor neuron) restoration, muscle strength and body weight. In type 2 diabetes mice, this compound not only lowers blood glucose but also attenuates hyperglycemia-induced inflammation, oxidative stress and apoptosis. It improves spatial memory in streptozotocin-induced diabetic rats and exhibits antiamnesic activity in scopolamine-treated mice via acetylcholinesterase inhibition[2].
References

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