Home Neuronal Signaling Adrenergic Receptor agonist Higenamine hydrochloride

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Higenamine hydrochloride Adrenergic Receptor agonist

Cat.No.S3960

Higenamine (Norcoclaurine, (+-)-Demethylcoclaurine), also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants.
Higenamine hydrochloride Adrenergic Receptor agonist Chemical Structure

Chemical Structure

Molecular Weight: 307.77

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Quality Control

Batch: S396001 DMSO]61 mg/mL]false]]]false]]]false Purity: 99.32%
99.32

Chemical Information, Storage & Stability

Molecular Weight 307.77 Formula

C16H17NO3.HCl

 Storage (From the date of receipt)
CAS No. 11041-94-4 -- Storage of Stock Solutions

Synonyms Norcoclaurine HCl, (+-)-Demethylcoclaurine hydrochloride Smiles C1CNC(C2=CC(=C(C=C21)O)O)CC3=CC=C(C=C3)O.Cl

Solubility

In vitro
Batch:

DMSO : 61 mg/mL (198.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

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Mass Concentration Volume Molecular Weight

In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Mechanism of Action

Targets/IC50/Ki
β2-adrenoceptor [1]
α1-adrenoceptor [1]
In vitro
Higenamine is a potential β2-adrenoceptor agonist. As a potent cardiotonic and vasodilator, It is also an α1 antagonist and a weak α2 agonist[1]. Higenamine decreases the intracellular dopamine content dose-dependently and shows 55.2% inhibition of dopamine content in PC12 cells at a concentration of 2OM with 24h incubation. The IC50 value of higenamine for inhibiting dopamine biosynthesis in PC12 cells is 18.2 μM. Dopamine content is lowered and reaches minimal level at 12—24h after exposure to higenamine[2].
In vivo
Higenamine can produce relaxation in tracheal muscle[1]. Higenamine has anti-thrombotic effects in both mouse acute thrombosis model and rat arterio-venous shunt (AV-shunt) models. The oral administration of higenamine (50 or 100 mg/kg) increases the recovery rates from the acute thrombotic challenge in mice and lowers the weight of thrombus formed inside the AV-shunt tube in rats[3].
References

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