Nobiletin (NSC 76751)

Catalog No.S2333 Synonyms: Hexamethoxyflavone

For research use only.

Nobiletin (NSC 76751, Hexamethoxyflavone), a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities.

Nobiletin (NSC 76751) Chemical Structure

CAS No. 478-01-3

Selleck's Nobiletin (NSC 76751) has been cited by 10 Publications

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Biological Activity

Description Nobiletin (NSC 76751, Hexamethoxyflavone), a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities.
Targets
MMP [1]
()
In vitro

Nobiletin, a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities. Nobiletin, a polymethoxyflavonoid, is identified as an inhibitor of both NO and O 2- generation. Nobiletin significantly inhibites two skin inflammation induced by double TPA application. It also suppresses the expression of cyclooxygenase-2 and inducible NO synthase proteins and prostaglandin E2 release. [1] Nobiletin inhibites the tumor-invasive activity of human fibrosarcoma HT-1080 cells in the Matrigel model, not only by suppressing the expression of MMPs but also augmenting TIMP-1 production through interfering the phosphatidylinositol 3-kinase pathway (PI3-K). [2] Nobiletin may also prevent atherosclerosis at the level of the vascular wall by inhibiting macrophage foam-cell formation. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF-7 MX NYTKXXVYTnWwY4Tpc44h[XO|YYm= NUizZYpOUW6qaXLpeIlwdiCxZjDCR3JRKGW6cILld5Nm\CCrbjDNR2YuPyCPWDDj[YxteyC3c3nu[{BJd2WlaIP0JFM{OzR{IIP0ZYlvcW6pLDDJR|UxRTRwNN88US=> NIDGTXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUO1OFgxOCd-MkGzOVQ5ODB:L3G+
MDCK MUHGeY5kfGmxbjDhd5NigQ>? NYX5Z5NKUW6qaXLpeIlwdiCxZjDCR3JRKGW6cILld5Nm\CCrbjDNSGNMKGOnbHzzJJV{cW6pIFjv[YNpe3RiM{OzOFIhe3SjaX7pcoctKEmFNUC9OE46|ryP MlzGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF|NUS4NFAoRjJzM{W0PFAxRC:jPh?=
NIH-3T3-G185 MYnGeY5kfGmxbjDhd5NigQ>? MU\UVH9VWkGQU2DPVnRGWjpiaX7obYJqfGmxbjDv[kBF[XWwb4L1ZolkcW5iZX\mcJV5KGmwIF7JTE0{XDNvR{G4OUBk\WyuczygTWM2OD1zMT61{txO MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTd2M{e0Nkc,OTF5NEO3OFI9N2F-
SRA 01/04 MoCySpVv[3Srb36gZZN{[Xl? MXKyOEBpenN? MofRTY5pcWKrdHnvckBw\iCWTl[tZYxxcGFvaX7keYNm\CCycn;NUXA6KHC{b3T1Z5Rqd25iaX6gbJVu[W5iU2LBJFAyNzB2IHPlcIx{KGGodHXyJFI1KGi{czDifUBUTFNvUFHHSUBidmGueYPpd{whUUN3ME2xO:69VQ>? MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTd{M{eyOkc,OjF5MkO3NlY9N2F-
SRA 01/04 MXrGeY5kfGmxbjDhd5NigQ>? NFnxUXMzPCCqcoO= MYnJcohq[mm2aX;uJI9nKFSQRnHsdIhiNXO2aX31cIF1\WRicILvJG1OWDlicILv[JVkfGmxbjDpckBpfW2jbjDTVmEhODFxMESgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KFOGUz3QRWdGKGKjc3XkJIdmdGG2aX6gfplud2e{YYDofUBie3OjeTygTWM2OD1zN988US=> NXuwNIxzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwOFc4QThpPkKyNFQ4Pzl6PD;hQi=>
SRA 01/04 M4TQWGZ2dmO2aX;uJIF{e2G7 MXiyOEBpenN? M{WxZ2lvcGmkaYTpc44hd2ZiUF3BMYlv\HWlZXSgdJJwVU2SOTDwdo9lfWO2aX;uJIlvKGi3bXHuJHNTSSByMT:wOEBk\WyuczDh[pRmeiB{NDDodpMh[nliU1TTMXBCT0ViYX7hcJl{cXNuIFnDOVA:OjBwOd88US=> NUO0e4JSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG3NlM4OjZpPkKxO|I{PzJ4PD;hQi=>
SRA 01/04 NWLt[2VzTnWwY4Tpc44h[XO|YYm= MYGyOEBpenN? MoPvTY5pcWKrdHnvckBw\iCSTVGtd5RqdXWuYYTl[EBxem9iTV3QPUBxem:mdXP0bY9vKGmwIHj1cYFvKFOUQTCwNU8xPCClZXzsd{Bi\nSncjCyOEBpenNiYomgV2RUNVCDR1WgZoF{\WRiZ3XsZZRqdiC8eX3v[5JieGi7IHHzd4F6NCCLQ{WwQVIxNjoQvF2= M3W5PVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MES3O|k5Lz5{MkC0O|c6QDxxYU6=
HT-29 NV7I[WJYSW62aXPhcoNmeiCjc4PhfS=> MWi3NkBpenN? M3TSPGFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIWE0zQSClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUK0{txO MkjBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyNUS2O|coRjF7MEW0Olc4RC:jPh?=
SHSY5Y MlTySpVv[3Srb36gZZN{[Xl? M2HvTVEzKGi{cx?= MV3S[YR2[3Srb36gc4YhcHmmcn;n[Y4heGW{b4jp[IUucW6mdXPl[EBieG:ydH;0bYMh[2WubDDk[YF1cCCrbjDoeY1idiCVSGPZOXkh[2WubIOgZZN{\XO|ZXSgZZMhTE6DIHzh[IRmeiCob4LtZZRqd25iYX\0[ZIhOTJiaILz M2X0eFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6MkiyO|U4Lz5zOEK4Nlc2PzxxYU6=
SHSY5Y M3HJeGZ2dmO2aX;uJIF{e2G7 NIPLfWs{OCC3TR?= NGi0XVk{KGi{cx?= MWrFcIV3[XSrb36gc4YheGixc4Doc5J6dGG2ZXSgSXJMKGyndnXsJIlvKGi7ZILv[4VvKHCncn;4bYRmNXS{ZXH0[YQhcHWvYX6gV2hUYTW\IHPlcIx{KGG2IEOwJJVOKGGodHXyJFMhcHK|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>? M13qUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6MkiyO|U4Lz5zOEK4Nlc2PzxxYU6=
SHSY5Y MXfGeY5kfGmxbjDhd5NigQ>? NXXZN4JROzBidV2= NVrpNFVtOyCqcoO= NY\XUlFuTWyndnH0bY9vKG:oIIDoc5NxcG:{eXzheIVlKHB|ODDs[ZZmdCCrbjDofYRzd2enbjDw[ZJwgGmmZT30doVifGWmIHj1cYFvKFOKU2m1XUBk\WyuczDheEA{OCC3TTDh[pRmeiB|IHjyd{BjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYO= NVfQfWI{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUiyPFI4PTdpPkG4NlgzPzV5PD;hQi=>
SHSY5Y NXT6dJIxTnWwY4Tpc44h[XO|YYm= MWKzNEB2VQ>? M3fuTFMhcHK| NWe1ZWxkTWyndnH0bY9vKG:oIIDoc5NxcG:{eXzheIVlKEqQazDs[ZZmdCCrbjDofYRzd2enbjDw[ZJwgGmmZT30doVifGWmIHj1cYFvKFOKU2m1XUBk\WyuczDheEA{OCC3TTDh[pRmeiB|IHjyd{BjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYO= MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDJ6Mke1O{c,OTh{OEK3OVc9N2F-
ST-13 MlnCSpVv[3Srb36gZZN{[Xl? MXyxNEB2VQ>? MlnVNVEh\GG7cx?= M{fQfWlv\HWldHnvckBw\iCycnXh[Ilxd2O7dHWg[Iln\mW{ZX70bYF1cW:wIHnuJI1wfXOnIGPUMVE{KGOnbHzzJIF{e2W|c3XkJIF{KGyrcHnkJIFk[3WvdXzheIlwdiCjdDCxNEB2VSC5aYTobY4hOTFiZHH5d{BjgSCxaXygdoVlNXO2YXnubY5oKHKnbHH0bZZmKHSxIHPvcpRzd2x? NV7BS2VrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyOlg2QDdpPkG5NlY5PTh5PD;hQi=>
ST-13 NYrKepRTTnWwY4Tpc44h[XO|YYm= MYqwMlEhfG9iM{CgeW0> M1jpc|EyKGSjeYO= NVPRRWlIUW6mdXP0bY9vKG:oIHHkbZBw[3m2ZTDkbYZn\XKnboTpZZRqd25iaX6gcY92e2ViU2StNVMh[2WubIOgZZN{\XO|ZXSgZZMhe3SrbYXsZZRqd25ib3[gZYRqeHOrbjDtVm5CKGW6cILld5Nqd25iYYSgNE4yKHSxIEOwJJVOKHerdHjpckAyOSCmYYnzJIJ6KHOnbXmtdZVidnSrdHH0bZZmKFKWLWDDVi=> MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ4OEW4O{c,OTl{Nki1PFc9N2F-
ST-13 MlLSSpVv[3Srb36gZZN{[Xl? MVKwMlEhfG9iM{CgeW0> MXqxNUBl[Xm| M3H4Zmlv\HWldHnvckBw\iCjZHnwc4N6fGViZHnm[oVz\W62aXH0bY9vKGmwIH3veZNmKFOWLUGzJINmdGy|IHHzd4V{e2WmIHHzJJN1cW23bHH0bY9vKG:oIHHkbZBw[3m2ZTDQNkBuWk6DIHX4dJJme3Orb36gZZQhOC5zIITvJFMxKHWPIIfpeIhqdiBzMTDkZZl{KGK7IIPlcYkueXWjboTpeIF1cX[nIGLUMXBEWg>? NGHEOlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUK2PFU5Pyd-MUmyOlg2QDd:L3G+
ST-13 M3\keGZ2dmO2aX;uJIF{e2G7 NH3QO2MyOSCmYYnz MVzJcoR2[3Srb36gc4Yh[WSrcH;jfZRmKGSrZn\ldoVvfGmjdHnvckBqdiCvb4Xz[UBUXC1zMzDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBRWEGUZ3HtcYEzKG2UTlGgcIV3\WxiYX\0[ZIhOTFiZHH5d{BjgSC|ZX3pMZF2[W62aYTheIl3\SCUVD3QR3IhemWuYYTpeoUhfG9iY3;ueJJwdA>? M{DvTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7Mk[4OVg4Lz5zOUK2PFU5PzxxYU6=
SRA 01/04 MVfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHXSNGo3PCC3TR?= MnjyOEBl[Xm| NVrRd|VDT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hW1KDIECxM|A1KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDQR25CKGW6cILld5Nqd25iYYSgOlQhfU1iYX\0[ZIhPCCmYYnzJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrcx?= NW\ROXdFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOxPVk5QDJpPkKzNVk6QDh{PD;hQi=>
In vivo LD50: 780mg/kg (i.g.). [4]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 81 mg/mL
(201.29 mM)
Ethanol 3 mg/mL
(7.45 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 402.39
Formula

C21H22O8

CAS No. 478-01-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles COC1=C(C=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C(=C3OC)OC)OC)OC)OC

In vivo Formulation Calculator (Clear solution)

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% DMSO % % Tween 80 % ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Molarity Calculator

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