Nobiletin (NSC 76751)

For research use only.

Catalog No.S2333 Synonyms: Hexamethoxyflavone

8 publications

Nobiletin (NSC 76751) Chemical Structure

CAS No. 478-01-3

Nobiletin (NSC 76751, Hexamethoxyflavone), a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities.

Selleck's Nobiletin (NSC 76751) has been cited by 8 publications

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  • NOB modulates Cps1 mRNA and protein expression. a Total protein extracts were prepared from liver samples collected from the four diet/treatment groups of wild-type mice at the indicated circadian time points (n = 3). Western blotting analysis was performed using anti-CPS1 antibody. RC regular chow, HFD high-fat diet, Veh vehicle, NOB Nobiletin. The results shown are representative of three independent experiments. See Additional file 1: Figure S1A for quantitative analysis. b Immunohistochemical staining of CPS1 in liver sections from mice with the indicated diet and treatment at ZT2. c Real-time RT-PCR analysis of Cps1 in liver samples collected as in (a). Data are presented as mean ± SEM (n = 3). Two-way ANOVA with Bonferroni post-hoc tests shows significant statistical differences between HFD.Veh and other three groups (p < 0.0001). d Western blotting analysis of protein lysates of liver samples collected at ZT 6 and 18 from mice with the indicated diet and treatment (n = 3). HPD indicates high-protein diet. The images shown to the left are representative of three independent experiments. Quantitation of Western blots was carried out and the results, presented as mean ± SEM, are shown in the lower panel. Two-way ANOVA with Bonferroni post-hoc tests, RC vs. HPD, ***p < 0.001. e Real-time qPCR analysis was carried out using total RNAs extracted from the liver samples described in (d). The results are presented as mean ± SEM. Two-way ANOVA with Bonferroni post-hoc tests, RC vs. HPD, *p < 0.05.

    Nutr Metab (Lond), 2015, 12:23.. Nobiletin (NSC 76751) purchased from Selleck.

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Description Nobiletin (NSC 76751, Hexamethoxyflavone), a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities.
Targets
MMP [1]
()
In vitro

Nobiletin, a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities. Nobiletin, a polymethoxyflavonoid, is identified as an inhibitor of both NO and O 2- generation. Nobiletin significantly inhibites two skin inflammation induced by double TPA application. It also suppresses the expression of cyclooxygenase-2 and inducible NO synthase proteins and prostaglandin E2 release. [1] Nobiletin inhibites the tumor-invasive activity of human fibrosarcoma HT-1080 cells in the Matrigel model, not only by suppressing the expression of MMPs but also augmenting TIMP-1 production through interfering the phosphatidylinositol 3-kinase pathway (PI3-K). [2] Nobiletin may also prevent atherosclerosis at the level of the vascular wall by inhibiting macrophage foam-cell formation. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF-7 MX MUfGeY5kfGmxbjDhd5NigQ>? MYfJcohq[mm2aX;uJI9nKEKFUmCg[ZhxemW|c3XkJIlvKE2FRj23JG1ZKGOnbHzzJJV{cW6pIFjv[YNpe3RiM{OzOFIhe3SjaX7pcoctKEmFNUC9OE41|ryP M2jXT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzM{W0PFAxLz5{MUO1OFgxODxxYU6=
MDCK MlPjSpVv[3Srb36gZZN{[Xl? NGPxO3NKdmirYnn0bY9vKG:oIFLDVnAh\XiycnXzd4VlKGmwIF3ER2sh[2WubIOgeZNqdmdiSH;lZ4h{fCB|M{O0NkB{fGGrbnnu[{whUUN3ME20MlnPxE1? NHTSXmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUO1OFgxOCd-MkGzOVQ5ODB:L3G+
NIH-3T3-G185 NUS0XpFxTnWwY4Tpc44h[XO|YYm= NGnkOZlVWF:WUlHOV3BQWlSHUkqgbY5pcWKrdHnvckBw\iCGYYXuc5J2[mmlaX6g[YZndHW6IHnuJG5KUC1|VEOtS|E5PSClZXzsd{whUUN3ME2xNU42|ryP MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTd2M{e0Nkc,OTF5NEO3OFI9N2F-
SRA 01/04 NHzwZZNHfW6ldHnvckBie3OjeR?= MYSyOEBpenN? Mo\xTY5pcWKrdHnvckBw\iCWTl[tZYxxcGFvaX7keYNm\CCycn;NUXA6KHC{b3T1Z5Rqd25iaX6gbJVu[W5iU2LBJFAyNzB2IHPlcIx{KGGodHXyJFI1KGi{czDifUBUTFNvUFHHSUBidmGueYPpd{whUUN3ME2xO:69VQ>? NH7kXVA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUeyN|czPid-MkG3NlM4OjZ:L3G+
SRA 01/04 MVvGeY5kfGmxbjDhd5NigQ>? NVvsNmRZOjRiaILz MWPJcohq[mm2aX;uJI9nKFSQRnHsdIhiNXO2aX31cIF1\WRicILvJG1OWDlicILv[JVkfGmxbjDpckBpfW2jbjDTVmEhODFxMESgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KFOGUz3QRWdGKGKjc3XkJIdmdGG2aX6gfplud2e{YYDofUBie3OjeTygTWM2OD1zN988US=> M{PMbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MES3O|k5Lz5{MkC0O|c6QDxxYU6=
SRA 01/04 M4jGWWZ2dmO2aX;uJIF{e2G7 NIfxXoEzPCCqcoO= MnzFTY5pcWKrdHnvckBw\iCSTVGtbY5lfWOnZDDwdo9OVVB7IIDyc4R2[3Srb36gbY4hcHWvYX6gV3JCKDBzL{C0JINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCVRGOtVGFITSCjbnHsfZNqeyxiSVO1NF0zOC57zszN MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTd{M{eyOkc,OjF5MkO3NlY9N2F-
SRA 01/04 MUTGeY5kfGmxbjDhd5NigQ>? MXyyOEBpenN? NIrVNXlKdmirYnn0bY9vKG:oIGDNRU1{fGmvdXzheIVlKHC{bzDNUXA6KHC{b3T1Z5Rqd25iaX6gbJVu[W5iU2LBJFAyNzB2IHPlcIx{KGGodHXyJFI1KGi{czDifUBUTFNvUFHHSUBj[XOnZDDn[YxifGmwIIr5cY9oemGyaImgZZN{[XluIFnDOVA:OjBwOd88US=> MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjB2N{e5PEc,OjJyNEe3PVg9N2F-
HT-29 NYe3NmpDSW62aXPhcoNmeiCjc4PhfS=> NUPWNnVCPzJiaILz NVTJVGpTSW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJGhVNTJ7IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NlTPxE1? NInS[WE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC1OFY4Pyd-MUmwOVQ3Pzd:L3G+
SHSY5Y NEfqc3ZHfW6ldHnvckBie3OjeR?= MV6xNkBpenN? NUexNW0xWmWmdXP0bY9vKG:oIHj5[JJw\2WwIIDldo95cWSnLXnu[JVk\WRiYYDvdJRwfGmlIHPlcIwh\GWjdHigbY4hcHWvYX6gV2hUYTW\IHPlcIx{KGG|c3Xzd4VlKGG|IFTORUBt[WSmZYKg[o9zdWG2aX;uJIFnfGW{IEGyJIhzew>? MlrjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh{OEK3OVcoRjF6MkiyO|U4RC:jPh?=
SHSY5Y M1[5NWZ2dmO2aX;uJIF{e2G7 NIPhVYI{OCC3TR?= M3T2XFMhcHK| NF7Sb5hGdGW4YYTpc44hd2ZicHjvd5Bpd3K7bHH0[YQhTVKNIHzleoVtKGmwIHj5[JJw\2WwIIDldo95cWSnLYTy[YF1\WRiaIXtZY4hW0iVWUXZJINmdGy|IHH0JFMxKHWPIHHmeIVzKDNiaILzJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrcx?= MnPPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh{OEK3OVcoRjF6MkiyO|U4RC:jPh?=
SHSY5Y M3jXTGZ2dmO2aX;uJIF{e2G7 NVHZ[nFUOzBidV2= MV:zJIhzew>? M2HEVGVt\X[jdHnvckBw\iCyaH;zdIhwenmuYYTl[EBxOzhibHX2[YwhcW5iaInkdo9o\W5icHXyc5hq\GVvdILlZZRm\CCqdX3hckBUUFO\NWmgZ4VtdHNiYYSgN|AhfU1iYX\0[ZIhOyCqcoOgZpkhX2W|dHXyckBjdG:2IHHuZYx6e2m| MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDJ6Mke1O{c,OTh{OEK3OVc9N2F-
SHSY5Y MlPHSpVv[3Srb36gZZN{[Xl? Ml7JN|AhfU1? M2jGXVMhcHK| MYPFcIV3[XSrb36gc4YheGixc4Doc5J6dGG2ZXSgTm5sKGyndnXsJIlvKGi7ZILv[4VvKHCncn;4bYRmNXS{ZXH0[YQhcHWvYX6gV2hUYTW\IHPlcIx{KGG2IEOwJJVOKGGodHXyJFMhcHK|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>? NF3oXFg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEK4Nlc2Pyd-MUiyPFI4PTd:L3G+
ST-13 M4SxXWZ2dmO2aX;uJIF{e2G7 MUSxNEB2VQ>? M3T6dVEyKGSjeYO= NF7oSJlKdmS3Y4Tpc44hd2ZicILlZYRqeG:leYTlJIRq\m[ncnXueIlifGmxbjDpckBud3W|ZTDTWE0yOyClZXzsd{Bie3Onc4Pl[EBieyCuaYDp[EBi[2O3bYXsZZRqd25iYYSgNVAhfU1id3n0bIlvKDFzIHThfZMh[nlib3nsJJJm\C2|dHHpcolv\yC{ZXzheIl3\SC2bzDjc451em:u NYi1dYp[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyOlg2QDdpPkG5NlY5PTh5PD;hQi=>
ST-13 NFLu[G5HfW6ldHnvckBie3OjeR?= NH\pdFcxNjFidH:gN|AhfU1? NVPHWVlMOTFiZHH5dy=> NITvUGNKdmS3Y4Tpc44hd2ZiYXTpdI9kgXSnIHTp[oZmemWwdHnheIlwdiCrbjDtc5V{\SCVVD2xN{Bk\WyuczDhd5Nme3OnZDDhd{B{fGmvdXzheIlwdiCxZjDh[Ilxe2mwIH3SUmEh\XiycnXzd4lwdiCjdDCwMlEhfG9iM{CgeW0hf2m2aHnuJFEyKGSjeYOgZpkhe2WvaT3xeYFvfGm2YYTpeoUhWlRvUFPS M4j3XVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7Mk[4OVg4Lz5zOUK2PFU5PzxxYU6=
ST-13 M1LBeGZ2dmO2aX;uJIF{e2G7 M1v5dVAvOSC2bzCzNEB2VQ>? M2mzPFEyKGSjeYO= NEC4OGJKdmS3Y4Tpc44hd2ZiYXTpdI9kgXSnIHTp[oZmemWwdHnheIlwdiCrbjDtc5V{\SCVVD2xN{Bk\WyuczDhd5Nme3OnZDDhd{B{fGmvdXzheIlwdiCxZjDh[Ilxd2O7dHWgVFIhdVKQQTDlfJBz\XO|aX;uJIF1KDBwMTD0c{A{OCC3TTD3bZRpcW5iMUGg[IF6eyCkeTDz[Y1qNXG3YX70bZRifGm4ZTDSWE1RS1J? NETWeZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUK2PFU5Pyd-MUmyOlg2QDd:L3G+
ST-13 NV7C[G1iTnWwY4Tpc44h[XO|YYm= NYK0WohiOTFiZHH5dy=> NG\sV2VKdmS3Y4Tpc44hd2ZiYXTpdI9kgXSnIHTp[oZmemWwdHnheIlwdiCrbjDtc5V{\SCVVD2xN{Bk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCSUFHS[4FudWF{IH3SUmEhdGW4ZXygZYZ1\XJiMUGg[IF6eyCkeTDz[Y1qNXG3YX70bZRifGm4ZTDSWE1RS1JicnXsZZRqfmVidH:gZ49vfHKxbB?= NH7wUGM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUK2PFU5Pyd-MUmyOlg2QDd:L3G+
SRA 01/04 MUjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHny[ow3PCC3TR?= NWDHe4sxPCCmYYnz MX\Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDTVmEhODFxMESgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKFCFTlGg[ZhxemW|c3nvckBifCB4NDD1UUBi\nSncjC0JIRigXNiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{ M3S2blxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MUm5PFgzLz5{M{G5PVg5OjxxYU6=

... Click to View More Cell Line Experimental Data

In vivo LD50: 780mg/kg (i.g.). [4]

Protocol

Solubility (25°C)

In vitro DMSO 81 mg/mL (201.29 mM)
Ethanol 3 mg/mL (7.45 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 402.39
Formula

C21H22O8

CAS No. 478-01-3
Storage powder
in solvent
Synonyms Hexamethoxyflavone
Smiles COC1=C(C=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C(=C3OC)OC)OC)OC)OC

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID