Catalog No.S3071 Synonyms: FEMA 3107

For research use only.

Vanillin (FEMA 3107), 4-hydroxy-3-methoxybenzaldehyde, is a food additive.

Vanillin Chemical Structure

CAS No. 121-33-5

Purity & Quality Control

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Biological Activity

Description Vanillin (FEMA 3107), 4-hydroxy-3-methoxybenzaldehyde, is a food additive.
In vitro

Vanillin is a phenolic aldehyde, an organic compound with the molecular formula C8H8O3. Vanilin is a flavorant present in foods, beverages, and tobacco. Vanilin has been evaluated as a potential agent to treat sickle cell anemia. Vanillin has moderate antisickling activity when compared with other aldehydes. Vanillin decreases HbS polymerization by a dual mechanism of action; allosteric modulation to a high-affinity HbS molecule and by stereospecific inhibition of T state HbS polymerization. [1]

In vivo Acute oral LD50 are as follows: rat, 1.58 g/kg, guinea pigs, 1.40 g/kg, and rabbits, 3.0 g/kg. Several oral toxicity studies with rats are reported in which high levels of vanillin are consumed for extensive periods without adverse effect. [1]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 152.15


CAS No. 121-33-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles COC1=C(C=CC(=C1)C=O)O

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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