Home Apoptosis Bcl-2 modulator - Caspase activator 10-Deacetyl-7-xylosyl paclitaxel For research use only.

10-Deacetyl-7-xylosyl paclitaxel

Synonyms: 10-Deacetyl-7-xylosyltaxol, 7-xylosyl-10-deacetylpaclitaxel

10-Deacetyl-7-xylosyl paclitaxel (10-Deacetyl-7-xylosyltaxol, 7-xylosyl-10-deacetylpaclitaxel), a derivative of paclitaxel and naturally occurring xyloside isolated from Taxus chinensis, causes significant mitotic arrest in PC-3 cells followed by up-regulating expression of pro-apoptotic Bax and Bad protein, as well as down-regulating expression of anti-apoptotic Bcl-2 and Bcl-XL , which leads to a disturbance of the mitochondrial membrane permeability and to the activation of caspase-9.

10-Deacetyl-7-xylosyl paclitaxel Chemical Structure

10-Deacetyl-7-xylosyl paclitaxel Chemical Structure

CAS: 90332-63-1

Selleck's 10-Deacetyl-7-xylosyl paclitaxel has been cited by 1 publication

Purity & Quality Control

Batch: S056301 DMSO] 100 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.38%
99.38

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Signaling Pathway

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Biological Activity

Description 10-Deacetyl-7-xylosyl paclitaxel (10-Deacetyl-7-xylosyltaxol, 7-xylosyl-10-deacetylpaclitaxel), a derivative of paclitaxel and naturally occurring xyloside isolated from Taxus chinensis, causes significant mitotic arrest in PC-3 cells followed by up-regulating expression of pro-apoptotic Bax and Bad protein, as well as down-regulating expression of anti-apoptotic Bcl-2 and Bcl-XL , which leads to a disturbance of the mitochondrial membrane permeability and to the activation of caspase-9.
Targets
Bax [1] Bad [1] Bcl-2 [1] Bcl-XL [1] caspase-9 [1]

Chemical Information & Solubility

Molecular Weight 943.98 Formula

C50H57NO17
CAS No. 90332-63-1 SDF --
Smiles CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)OC8C(C(C(CO8)O)O)O)C)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (105.93 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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