Molecular Weight(MW): 284.35
Dihydroartemisinin (DHA) is a semi-synthetic derivative of artemisinin and isolated from the traditional Chinese herb Artemisia annua.
Cited by 7 Publications
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(D) Western Blot analysis of TCTP in cell lysates of MDA cells after 24, 48 and 72 h of exposition to DHA. β-actin was used as loading control.
Oncotarget, 2015, 6(7):5275-91.. Dihydroartemisinin (DHA) purchased from Selleck.
In the migration assays, the TCTP-positive cell lines NOZ, GBC-SD, and OCUG-1, and the TCTP-negative cell lines EH-GB-2 and SGC-996 were pre-treated with either vehicle or DHA (40 μM) for 2 days and then seeded in transwell plates for 24 h.
J Exp Clin Cancer Res, 2017, 36(1):68. Dihydroartemisinin (DHA) purchased from Selleck.
Overexpression of GLUT1 inhibits cell death triggered by DHA. A549 and PC-9 cells were transfected with control (Ctr) and GLUT1 vector for 8 h respectively, and then treated with the indicated concentration of DHA for 48 h. (A) Cell lysates were subjected to western blot analysis with the indicated antibodies. (B) Cell growth inhibition activity was assessed by MTT. This experiment was repeated thrice. Columns, mean; bars, SD. ***, P < 0.001.
PLoS One, 2015, 10(3):e0120426.. Dihydroartemisinin (DHA) purchased from Selleck.
Purity & Quality Control
|Description||Dihydroartemisinin (DHA) is a semi-synthetic derivative of artemisinin and isolated from the traditional Chinese herb Artemisia annua.|
Dihydroartemisinin (DHA) inhibits the growth of certain cancer cell lines and xenograft tumors such as leukemia, glioma, fibrosarcoma, and breast, cervical, ovarian, lung, oral and pancreatic cancer. DHA inhibits cell and tumor growth by modulating various tumor-suppressive pathways, such as inhibiting cell proliferation and inducing apoptosis through regulation of proliferation- and apoptosis-related proteins.DHA inhibits the proliferation and viability of cells in a dose-dependent manner and induces apoptosis.DHA-mediated cytotoxicity is tumor selective. The endoperoxide bridge of DHA is reportedly essential for its cytotoxicity because it reacts with intracellular ferrous iron to generate reactive oxygen species or carbon-centered radicals, leading to cytotoxicity.
|In vivo||DHA significantly inhibited HCC cell growth in vitro and in vivo via inducing G2/M cell cycle arrest and apoptosis. DHA has been shown in the rat whole embryo culture (WEC) to primarily affect primitive red blood cells (RBCs) causing subsequent tissue damage and dysmorphogenesis.|
|In vitro||DMSO||56 mg/mL warmed (196.94 mM)|
|Ethanol||11 mg/mL warmed (38.68 mM)|
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Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03402789||Not yet recruiting||Drug: Docosahexaenoic Acid|Drug: Placebo Oral Tablet||Amblyopia||Johns Hopkins University||January 1 2020||Phase 1|Phase 2|
|NCT03937206||Active not recruiting||Dietary Supplement: NutriterraTM|Dietary Supplement: Placebo||Healthy||Nuseed Americas Inc.|Nutrasource Diagnostics Inc.||May 1 2019||Phase 1|Phase 2|
|NCT03576989||Recruiting||Dietary Supplement: EPA+DHA|Other: placebo||Chronic Venous Leg Ulcers||Ohio State University|National Institute on Aging (NIA)||April 15 2019||Not Applicable|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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