Naringin

Catalog No.S2329 Synonyms: Naringoside

Naringin Chemical Structure

Molecular Weight(MW): 580.53

Naringin is a flavanone glycoside, which exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of cytochrome P450 enzymes.

Size Price Stock Quantity  
In DMSO USD 420 In stock
USD 50 In stock
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Biological Activity

Description Naringin is a flavanone glycoside, which exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of cytochrome P450 enzymes.
Targets
P450 [1]
In vitro

Naringin is a flavanone glycoside, which gives the grapefruit juice its bitter taste. Naringin inhibits hepatic P-glycoprotein (P-gp) and some drug-metabolizing cytochrome P450 enzymes, including CYP3A4 and CYP1A2, which may result in drug-drug interactions. [1] Naringin is also an inhibitor of vascular endothelial growth factor (VEGF) release, which causes angiogenesis. [2] In addition, Naringin reduces diabetes-induced neuropathy in rats. [3]

In vivo LD50: Mice 1650mg/kg. [4]

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (172.25 mM)
Ethanol 2 mg/mL (3.44 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 580.53
Formula

C27H32O14

CAS No. 10236-47-2
Storage powder
in solvent
Synonyms Naringoside

Bio Calculators

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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P450 (e.g. CYP17) Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID