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Phytol PPAR activator

Cat.No.S5121

Phytol (Trans-Phytol), a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activities as well as anti-inflammatory and antiallergic effects. It is a specific activator of PPARα.
Phytol PPAR activator Chemical Structure

Chemical Structure

Molecular Weight: 296.53

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Chemical Information, Storage & Stability

Molecular Weight 296.53 Formula

C20H40O

 Storage (From the date of receipt) 2 years  -20°C  liquid
CAS No. 150-86-7 -- Storage of Stock Solutions

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Mechanism of Action

Targets/IC50/Ki
PPARα [3]
In vitro
Phytol, a branched-chain fatty alcohol, is the naturally occurring precursor of phytanic and pristanic acid, branched-chain fatty acids that are both ligands for the nuclear hormone receptor peroxisome proliferator-activated receptor α (PPARα)[1]. The addition of this compound upregulates the expression of PPARα-target genes at both mRNA and protein levels in PPARα-expressing HepG2 hepatocytes. It is a specific ligand for PPARα, although it can activate PPARγ moderately[3]. In vitro, this chemical reduces the motor activity of worms and causes their death. Additionally, it at sublethal doses (25 µg/mL) reduces the number of Schistosoma mansoni eggs[4].
In vivo
In many animal studies, phytol is used as a precursor of phytanic acid. Addition of this compound to the diet results in an increase of phytol metabolites in tissues and plasma[1]. In vivo, a single dose of this chemical (40 mg/kg) administered orally to mice infected with adult S. mansoni results in total and female worm burden reductions of 51.2% and 70.3%, respectively. Moreover, it reduces the number of eggs in faeces (76.6%) and the frequency of immature eggs (oogram pattern) is significantly reduced. In medicinal fields, this compound has shown antinociceptive and antioxidant activities as well as anti-inflammatory and antiallergic effects. It is an excellent immunostimulant, superior to a number of commercial adjuvants in terms of long-term memory induction and activation of both innate and acquired immunity[4].
References

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