Phytol

For research use only.

Catalog No.S5121 Synonyms: Trans-Phytol

Phytol Chemical Structure

CAS No. 150-86-7

Phytol (Trans-Phytol), a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activities as well as anti-inflammatory and antiallergic effects. It is a specific activator of PPARα.

Purity & Quality Control

Choose Selective PPAR Inhibitors

Biological Activity

Description Phytol (Trans-Phytol), a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activities as well as anti-inflammatory and antiallergic effects. It is a specific activator of PPARα.
Targets
PPARα [3]
()
In vitro

Phytol, a branched-chain fatty alcohol, is the naturally occurring precursor of phytanic and pristanic acid, branched-chain fatty acids that are both ligands for the nuclear hormone receptor peroxisome proliferator-activated receptor α (PPARα)[1]. The addition of phytol upregulates the expression of PPARα-target genes at both mRNA and protein levels in PPARα-expressing HepG2 hepatocytes. Phytol is a specific ligand for PPARα, although it can activate PPARγ moderately[3]. In vitro, phytol reduces the motor activity of worms and causes their death. Additionally, phytol at sublethal doses (25 µg/mL) reduces the number of Schistosoma mansoni eggs[4].

In vivo In many animal studies, phytol is used as a precursor of phytanic acid. Addition of phytol to the diet results in an increase of phytol metabolites in tissues and plasma[1]. In vivo, a single dose of phytol (40 mg/kg) administered orally to mice infected with adult S. mansoni results in total and female worm burden reductions of 51.2% and 70.3%, respectively. Moreover, phytol reduces the number of eggs in faeces (76.6%) and the frequency of immature eggs (oogram pattern) is significantly reduced. In medicinal fields, phytol has shown antinociceptive and antioxidant activities as well as anti-inflammatory and antiallergic effects. Phytol is an excellent immunostimulant, superior to a number of commercial adjuvants in terms of long-term memory induction and activation of both innate and acquired immunity[4].

Protocol

Cell Research:

[2]

- Collapse
  • Cell lines: Molt 4B cells
  • Concentrations: 10, 20, 40, 80, 100 μM
  • Incubation Time: 3 days
  • Method:

    Exponentially growing cells are placed at 3 to 4×l05 cells/ml in the culture flask and cultivated in the presence of vehicle or phytol. After cultivation for 3 days, the cell number is counted by a hemocytometer.


    (Only for Reference)
Animal Research:

[4]

- Collapse
  • Animal Models: Balb/c mice infected with S. mansoni
  • Dosages: 40 mg/kg
  • Administration: oral
    (Only for Reference)

Solubility (25°C)

Chemical Information

Molecular Weight 296.53
Formula

C20H40O

Density 0.8 g/mL
CAS No. 150-86-7
Storage 2 years -20°C liquid
Synonyms Trans-Phytol
Smiles CC(C)CCCC(C)CCCC(C)CCCC(=CCO)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

PPAR Signaling Pathway Map

Related PPAR Products

Tags: buy Phytol | Phytol supplier | purchase Phytol | Phytol cost | Phytol manufacturer | order Phytol | Phytol distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID