Sinomenine

Synonyms: Cucoline, Kukoline

Sinomenine (Cucoline, Kukoline), a pure alkaloid extracted from the chinese medical plant Sinomenium acutum, is used for the treatment of rheumatism and arthritis.

Sinomenine Chemical Structure

Sinomenine Chemical Structure

CAS: 115-53-7

Selleck's Sinomenine has been cited by 13 Publications

3 Customer Reviews

Purity & Quality Control

Batch: Purity: 99.99%
99.99

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Biological Activity

Description Sinomenine (Cucoline, Kukoline), a pure alkaloid extracted from the chinese medical plant Sinomenium acutum, is used for the treatment of rheumatism and arthritis.
In vitro
In vitro Sinomenine, a pure alkaloid extracted from the chinese medical plant Sinomenium acutum, is used for the treatment of rheumatism and arthritis. [1] However its analgesic action against other kinds of pain is limited. Sinomenine is a morphinan derivative, related to opioids such as levorphanol and the non-opioid cough suppressant dextromethorphan. [2] Its anti-rheumatic effects are thought to be primarily mediated via release of histamine, but other effects such as inhibition of prostaglandin, leukotriene and nitric oxide synthesis may also be involved. [3]

Chemical Information & Solubility

Molecular Weight 329.39 Formula

C19H23NO4

CAS No. 115-53-7 SDF Download Sinomenine SDF
Smiles CN1CCC23CC(=O)C(=CC2C1CC4=C3C(=C(C=C4)OC)O)OC
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 65 mg/mL ( (197.33 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 65 mg/mL

Ethanol : 65 mg/mL


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In vivo
Batch:

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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