For research use only.
Catalog No.S2359 Synonyms: Cucoline, Kukoline
Molecular Weight(MW): 329.39
Sinomenine, a pure alkaloid extracted from the chinese medical plant Sinomenium acutum, is used for the treatment of rheumatism and arthritis.
Selleck's Sinomenine has been cited by 6 publications
3 Customer Reviews
Cells were treated with sinomenine for 24 h. The expressions of S phase cell cycle-regulating proteins were measured by western blot analysis.
Int J Oncol, 2016, 48(5):2098-112. Sinomenine purchased from Selleck.
Repeated i.p administration of sinomenine reversed TCI-induced upregulation of JAK2/STAT3 pathway in the spinal cord. (a to d) Western blot data summary showing that sinomenine decreased the protein expression of p-JAK2 and p-STAT3 (***p < 0.001 compared with the sham + vehicle group; ###p < 0.001 compared with the CIBP + vehicle group, n = 6 in each group). Sinomenine (i.p, 40 mg/kg) or vehicle was administered once a day from day 14 after TCI to day 18. Tissues were collected 2 h after the last injection. GAPDH: glyceraldehyde-3-phosphate dehydrogenase antibody; CIBP: cancer-induced bone pain; p-JAK2: phosphorylated-Janus family tyrosine kinase 2; p-STAT: phosphorylated-signal transducers and activatorsof transcription 3.
Mol Pain, 2018, doi:10.1177/1744806918793232. Sinomenine purchased from Selleck.
SINO reduced neuronal loss and apoptosis after MCAO. A-B. Nissl staining and quantitative analysis of neuronal survival at 72 h after MCAO (n = 5). Scale bar = 100 μm. C–D. Western blot and quantitative analysis of cleaved caspase-3 expression in the ischemic hemisphere at 72 h after MCAO (n = 5). Data are means ± SEM, *P < 0.05 and **P < 0.01, vs. sham group; #P < 0.05 and ##P < 0.01 vs. the indicated groups. SINO-10: 10 mg/kg SINO; SINO-20: 20 mg/kg SINO.
Int Immunopharmacol, 2016, 40:492-500.. Sinomenine purchased from Selleck.
Purity & Quality Control
|Description||Sinomenine, a pure alkaloid extracted from the chinese medical plant Sinomenium acutum, is used for the treatment of rheumatism and arthritis.|
Sinomenine, a pure alkaloid extracted from the chinese medical plant Sinomenium acutum, is used for the treatment of rheumatism and arthritis.  However its analgesic action against other kinds of pain is limited. Sinomenine is a morphinan derivative, related to opioids such as levorphanol and the non-opioid cough suppressant dextromethorphan.  Its anti-rheumatic effects are thought to be primarily mediated via release of histamine, but other effects such as inhibition of prostaglandin, leukotriene and nitric oxide synthesis may also be involved. 
|In vitro||DMSO||65 mg/mL (197.33 mM)|
|Water||65 mg/mL warmed (197.33 mM)|
|Ethanol||7 mg/mL (21.25 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
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Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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