L-Tryptophan

Catalog No.S3987

For research use only.

L-tryprophan is an essential amino acid that acts like a natural mood regulator that is necessary for normal growth in infants and for nitrogen balance in adults.

L-Tryptophan Chemical Structure

CAS No. 73-22-3

Purity & Quality Control

Related Other Products

Biological Activity

Description L-tryprophan is an essential amino acid that acts like a natural mood regulator that is necessary for normal growth in infants and for nitrogen balance in adults.
In vivo L-Tryptophan suppresses both serum glucose and insulin levels after oral glucose administration and inhibits glucose absorption from the intestine. It increases glucose-associated energy expenditure in rats in vivo. L-Tryptophan suppresses the rapid rise in blood glucose after a glucose-rich meal and lessens the burden of insulin secretion from β-cells. Oral administration of L-tryptophan is more effective than intraperitoneal injection[1].

Protocol (from reference)

Animal Research:

[1]

  • Animal Models: Four-week-old male normal Sprague-Dawley rats
  • Dosages: 62.5 mg/kg
  • Administration: Oral administration
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 11 mg/mL
(53.86 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 204.23
Formula

C11H12N2O2

CAS No. 73-22-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)N

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05155631 Not yet recruiting Behavioral: COGNITIVE BEHAVIORAL THERAPY IBS - Irritable Bowel Syndrome University of California Los Angeles December 18 2021 Not Applicable
NCT05083637 Not yet recruiting Drug: L- carnitine oral solution|Other: Placebo Malnutrition International Centre for Diarrhoeal Disease Research Bangladesh October 10 2021 Not Applicable
NCT04804358 Recruiting Behavioral: Exposition Test Anorexia Nervosa University Hospital Montpellier September 17 2021 Not Applicable
NCT04949607 Not yet recruiting Dietary Supplement: Inulin fructooligosaccharide Brain Injury Chronic|Brain Injuries Traumatic Centre for Neuro Skills|University of Texas July 1 2021 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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