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L-Tryptophan Amino Acids and Derivatives chemical

Name: L-Tryptophan
Brand: Selleck Chemicals
SKU: S3987
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S3987

L-tryprophan is an essential amino acid that acts like a natural mood regulator that is necessary for normal growth in infants and for nitrogen balance in adults.

Chemical Structure

Molecular Weight: 204.23

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Quality Control

Batch: S398701 DMSO]11 mg/mL]false]]]false]]]false Purity: 99.28%

Cited in Nature Medicine for its top-tier quality
COA
SDS
Datasheet

99.28

Related Targets	Dehydrogenase HSP Transferase P450 (e.g. CYP17) PDE phosphatase PPAR Vitamin Carbohydrate Metabolism Mitochondrial Metabolism
Other Amino Acids and Derivatives Inhibitors	(±)-Alliin L-Ornithine Aceglutamide Acetylleucine Selenomethionine 4-Aminohippuric Acid Afalanine (N-Acetyl-DL-phenylalanine) Tos-Arg-OMe HCl DL-O-Tyrosine isoleucine

Solubility

In vitro
Batch:

DMSO : 11 mg/mL (53.86 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.550mg/ml (2.69mM)	Taking the 1 mL working solution as an example, add 50 μL of 11 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.090mg/ml (0.44mM)	Taking the 1 mL working solution as an example, add 50 μL of 1.8 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	204.23	Formula	C₁₁H₁₂N₂O₂	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	73-22-3	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Mechanism of Action

In vivo

L-Tryptophan suppresses both serum glucose and insulin levels after oral glucose administration and inhibits glucose absorption from the intestine. It increases glucose-associated energy expenditure in rats in vivo. This compound suppresses the rapid rise in blood glucose after a glucose-rich meal and lessens the burden of insulin secretion from β-cells. Oral administration of this chemical is more effective than intraperitoneal injection.

References

[1] https://www.jstage.jst.go.jp/article/jnsv/58/6/58_415/_pdf

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06283706	Not yet recruiting	Healthy Aging	The Hospital for Sick Children\|Canadian Institutes of Health Research (CIHR)	June 1 2024	Not Applicable
NCT06365801	Not yet recruiting	Irritable Bowel Syndrome	The Third Affiliated hospital of Zhejiang Chinese Medical University	April 2024	--
NCT06228352	Not yet recruiting	Ulcerative Colitis	Assistance Publique - Hôpitaux de Paris	March 2024	--
NCT06021535	Not yet recruiting	Aortic Stenosis\|Gastrointestinal Microbiome\|Metabolomics	Insel Gruppe AG University Hospital Bern	January 1 2024	--

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Handling Instructions

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