Home Cytoskeletal Signaling PKC inhibitor 2-Methoxy-1,4-naphthoquinone

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2-Methoxy-1,4-naphthoquinone PKC inhibitor

Cat.No.S3661

2-Methoxy-1,4-naphthoquinone, isolated from the leaves of Impatiens glandulifera, specifically suppressed the expression of PKC βI, δ, and ζ in a concentration-dependent manner in Raji cells.
2-Methoxy-1,4-naphthoquinone PKC inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 188.18

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Quality Control

Batch: S366101 DMSO]37 mg/mL]false]Ethanol]3 mg/mL]false]Water]Insoluble]false Purity: 99.61%
99.61

Solubility

In vitro
Batch:

DMSO : 37 mg/mL (196.62 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 3 mg/mL

Water : Insoluble

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In vivo
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Chemical Information, Storage & Stability

Molecular Weight 188.18 Formula

C11H8O3

 Storage (From the date of receipt)
CAS No. 2348-82-5 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles COC1=CC(=O)C2=CC=CC=C2C1=O

Mechanism of Action

Targets/IC50/Ki
PKCβ1
PKCδ
PKCζ
In vitro
2-Methoxy-1,4-naphthoquinone (MNQ) exhibits antifungal, antimicrobial activities and showed strong killing effect on K562, HL-60, Raji, MCF-7, H-23, IMR-32, LA-174-T, HSC-2, and SK-MEL-28. MNQ is able to trigger the intrinsic apoptotic pathway in K562 cells, as well as causing p53-dependent cell cycle arrest in the p53-wild type cell line. MNQ inhibits the TCF/β-catenin (TOP) transcriptional activity at IC50 2.9 μM, while it decreases the transcriptional activity of FOP (mutated TCF-binding site)-transfected cell. MNQ exerts an anti-metastatic effect against MDA-MB-231 cells. MNQ has remarkable selectivity towards PKCβI and ζ suppression. MNQ suppresses PKCδ moderately, where MNQ suppresses half of the PKCδ expression at the concentration of 10 μM. MNQ does not suppress PKC βII. MNQ is able to inhibit the invasion and migration characteristics of a highly metastatic MDA-MB-231 cancer cell line.
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