Home Cytoskeletal Signaling PKC inhibitor 2-Methoxy-1,4-naphthoquinone

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2-Methoxy-1,4-naphthoquinone PKC inhibitor

Cat.No.S3661

2-Methoxy-1,4-naphthoquinone, isolated from the leaves of Impatiens glandulifera, specifically suppressed the expression of PKC βI, δ, and ζ in a concentration-dependent manner in Raji cells.
2-Methoxy-1,4-naphthoquinone PKC inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 188.18

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Quality Control

Batch: S366101 DMSO]37 mg/mL]false]Ethanol]3 mg/mL]false]Water]Insoluble]false Purity: 99.61%
99.61

Chemical Information, Storage & Stability

Molecular Weight 188.18 Formula

C11H8O3

 Storage (From the date of receipt)
CAS No. 2348-82-5 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles COC1=CC(=O)C2=CC=CC=C2C1=O

Solubility

In vitro
Batch:

DMSO : 37 mg/mL (196.62 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 3 mg/mL

Water : Insoluble

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In vivo
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Mechanism of Action

Targets/IC50/Ki
PKCβ1 [1]
PKCδ [1]
PKCζ [1]
In vitro
2-Methoxy-1,4-naphthoquinone (MNQ) exhibits antifungal, antimicrobial activities and showed strong killing effect on K562, HL-60, Raji, MCF-7, H-23, IMR-32, LA-174-T, HSC-2, and SK-MEL-28. MNQ is able to trigger the intrinsic apoptotic pathway in K562 cells, as well as causing p53-dependent cell cycle arrest in the p53-wild type cell line. MNQ inhibits the TCF/β-catenin (TOP) transcriptional activity at IC50 2.9 μM, while it decreases the transcriptional activity of FOP (mutated TCF-binding site)-transfected cell. MNQ exerts an anti-metastatic effect against MDA-MB-231 cells. MNQ has remarkable selectivity towards PKCβI and ζ suppression. MNQ suppresses PKCδ moderately, where MNQ suppresses half of the PKCδ expression at the concentration of 10 μM. MNQ does not suppress PKC βII[1]. MNQ is able to inhibit the invasion and migration characteristics of a highly metastatic MDA-MB-231 cancer cell line[2].
References

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