Catalog No.S2403 Synonyms: Fanchinine
Molecular Weight(MW): 622.75
Tetrandrine, a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker.
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(B) Measurement of the cellular LDs in 3T3-L1 preadipocytes (undifferentiated) or differentiated adipocytes on day 8 by Oil Red O staining. Phase-contrast images of the cells were also taken after the treatment (lower panels in B). Each picture in (B) is a representative of three independent experiments. (C) Quantification of the cellular TG contents in tetrandrine-treated 3T3-L1 preadipocytes on day 8 by AdipoRed assay. Values are mean ± SE of data from three independent experiments with three replicates. *P < 0.05 vs.control (no chemical). (D) 3T3-L1 preadipocytes were grown under the above-mentioned 3T3-L1 preadipocyte differentiation condition in Figure 1A. On day 8, tetrandrine-treated 3T3-L1 preadipocytes, which cannot be stained with trypan blue dye, was counted under microscope. The cell count assay was done in triplicates. Data are mean ± SE of three independent experiments. *P < 0.05 vs. control (no chemical).
Biochemical and Biophysical Research Communications, 2016, 476(4):481-486.. Tetrandrine purchased from Selleck.
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Choose Selective Calcium Channel Inhibitors
|Description||Tetrandrine, a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker.|
Tetrandrine inhibits voltage-gated Ca2+ currents with an IC50 of 10.1 mM in isolated nerve terminals of the rat neurohypophysis. Tetrandrine is a high-affinity blocker of the type II, maxi-Ca(2+)-activated K+ channel of the rat neurohypophysial terminals with an IC50 of 0.21 mM.  Another study shows that Tetrandrine also inhibits Ca(2+)-activated Cl- currents (I(Cl,Ca)) with an IC50 of 5.2 mM.  Tetrandrine inhibits the proliferation of human leukemic HL-60 cells via induction of apoptosis. 
|In vivo||LD50: Mice 158.9mg/kg (i.v.) , 365mg/kg (i.p.) ; Rats 646mg/kg (i.g.) |
|In vitro||Ethanol||2 mg/mL (3.21 mM)|
|DMSO||1 mg/mL warmed (1.6 mM)|
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