Catalog No.S2403 Synonyms: Fanchinine

Tetrandrine Chemical Structure

Molecular Weight(MW): 622.75

Tetrandrine, a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker.

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Cited by 4 Publications

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  • BMMs were seeded in a collage I-coated plate and incubated with RANKL (100 ng/ml) and M-CSF (50 ng/ml) for 5 d. When mature osteoclasts were observed, they were digested by collagenase and seeded on bovine bone slices. The bone slices were treated with or without tetrandrine for an additional 2 d. Then, the cells were stained with rhodamine–phalloidin to observe the F-actin rings, and the areas of F-actin rings were calculated by Image-Pro Plus 6.0 software.

    FASEB J, 2018, 32(6):3398-3410. Tetrandrine purchased from Selleck.

    (B) Measurement of the cellular LDs in 3T3-L1 preadipocytes (undifferentiated) or differentiated adipocytes on day 8 by Oil Red O staining. Phase-contrast images of the cells were also taken after the treatment (lower panels in B). Each picture in (B) is a representative of three independent experiments. (C) Quantification of the cellular TG contents in tetrandrine-treated 3T3-L1 preadipocytes on day 8 by AdipoRed assay. Values are mean ± SE of data from three independent experiments with three replicates. *P < 0.05 vs.control (no chemical). (D) 3T3-L1 preadipocytes were grown under the above-mentioned 3T3-L1 preadipocyte differentiation condition in Figure 1A. On day 8, tetrandrine-treated 3T3-L1 preadipocytes, which cannot be stained with trypan blue dye, was counted under microscope. The cell count assay was done in triplicates. Data are mean ± SE of three independent experiments. *P < 0.05 vs. control (no chemical).

    Biochemical and Biophysical Research Communications, 2016, 476(4):481-486.. Tetrandrine purchased from Selleck.

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Biological Activity

Description Tetrandrine, a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker.
Calcium channel [1]
In vitro

Tetrandrine inhibits voltage-gated Ca2+ currents with an IC50 of 10.1 mM in isolated nerve terminals of the rat neurohypophysis. Tetrandrine is a high-affinity blocker of the type II, maxi-Ca(2+)-activated K+ channel of the rat neurohypophysial terminals with an IC50 of 0.21 mM. [1] Another study shows that Tetrandrine also inhibits Ca(2+)-activated Cl- currents (I(Cl,Ca)) with an IC50 of 5.2 mM. [2] Tetrandrine inhibits the proliferation of human leukemic HL-60 cells via induction of apoptosis. [3]

In vivo LD50: Mice 158.9mg/kg (i.v.) [4], 365mg/kg (i.p.) [5]; Rats 646mg/kg (i.g.) [6]


Solubility (25°C)

In vitro Ethanol 2 mg/mL (3.21 mM)
DMSO 1 mg/mL warmed (1.6 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 622.75


CAS No. 518-34-3
Storage powder
in solvent
Synonyms Fanchinine

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID