Tetrandrine (NSC-77037)

Catalog No.S2403 Synonyms: Fanchinine, d-Tetrandrine

For research use only.

Tetrandrine (NSC-77037, Fanchinine, d-Tetrandrine), a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker.

Tetrandrine (NSC-77037) Chemical Structure

CAS No. 518-34-3

Selleck's Tetrandrine (NSC-77037) has been cited by 8 Publications

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Biological Activity

Description Tetrandrine (NSC-77037, Fanchinine, d-Tetrandrine), a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker.
Targets
Calcium channel [1]
In vitro

Tetrandrine inhibits voltage-gated Ca2+ currents with an IC50 of 10.1 mM in isolated nerve terminals of the rat neurohypophysis. Tetrandrine is a high-affinity blocker of the type II, maxi-Ca(2+)-activated K+ channel of the rat neurohypophysial terminals with an IC50 of 0.21 mM. [1] Another study shows that Tetrandrine also inhibits Ca(2+)-activated Cl- currents (I(Cl,Ca)) with an IC50 of 5.2 mM. [2] Tetrandrine inhibits the proliferation of human leukemic HL-60 cells via induction of apoptosis. [3]

Assay
Methods Test Index PMID
Western blot p-GSK3β / GSK3β / p-β-catenin / β-catenin ; Atg7 ; p-ASK1 / ASK1 / p-SEK1 / SEK1 / p-JNK1/2 / JNK1/2 29334999 22927446 25181458
Growth inhibition assay Cell viability 29285984
Immunofluorescence E-cadherin / Vimentin ; p-STAT3 29334999 28332288
In vivo LD50: Mice 158.9mg/kg (i.v.) [4], 365mg/kg (i.p.) [5]; Rats 646mg/kg (i.g.) [6]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 622.75
Formula

C38H42N2O6

CAS No. 518-34-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)OC)OC

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