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Tetrandrine

Name: Tetrandrine
Brand: Selleck Chemicals
SKU: S2403
Rating: 5 (13 reviews)

Synonyms: NSC-77037, Fanchinine, d-Tetrandrine

Catalog No.S2403 Purity: 99.95%

Tetrandrine, a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker.

Tetrandrine Chemical Structure

CAS: 518-34-3

Selleck's Tetrandrine has been cited by 13 Publications

2 Customer Reviews

Purity & Quality Control

Batch: Purity: 99.95%

99.95

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Signaling Pathway

Calcium Channel Signaling Pathway

Choose Selective Calcium Channel Inhibitors

Biological Activity

Description

Tetrandrine, a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker.

Targets

Calcium channel ^[1]

In vitro
In vitro	Tetrandrine inhibits voltage-gated Ca2+ currents with an IC50 of 10.1 mM in isolated nerve terminals of the rat neurohypophysis. Tetrandrine is a high-affinity blocker of the type II, maxi-Ca(2+)-activated K+ channel of the rat neurohypophysial terminals with an IC50 of 0.21 mM. ^[1] Another study shows that Tetrandrine also inhibits Ca(2+)-activated Cl- currents (I(Cl,Ca)) with an IC50 of 5.2 mM. ^[2] Tetrandrine inhibits the proliferation of human leukemic HL-60 cells via induction of apoptosis. ^[3]
Experimental Result Images	Methods	Biomarkers	Images	PMID
	Western blot	p-GSK3β / GSK3β / p-β-catenin / β-catenin Atg7 p-ASK1 / ASK1 / p-SEK1 / SEK1 / p-JNK1/2 / JNK1/2		29334999
	Growth inhibition assay	Cell viability		29285984
	Immunofluorescence	E-cadherin / Vimentin p-STAT3		29334999

In Vivo
In vivo	LD50: Mice 158.9mg/kg (i.v.) ^[4], 365mg/kg (i.p.) ^[5]; Rats 646mg/kg (i.g.) ^[6]

References

Chemical Information & Solubility

Molecular Weight	622.75	Formula	C₃₈H₄₂N₂O6
CAS No.	518-34-3	SDF	Download Tetrandrine SDF
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 12 mg/mL ( (19.26 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 3 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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