Name: Inosine
Brand: Selleck Chemicals
SKU: S2442
Availability: InStock
Rating: 5 (4 reviews)

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Quality Control

Batch: Purity: 99.79%

99.79

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Solubility

In vitro
Batch:

DMSO : 53 mg/mL (197.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 47 mg/mL

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	268.23	Formula	C₁₀H₁₂N₄O₅	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	58-63-9	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	NSC 20262, INO 495			SMILES	C1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)CO)O)O

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

In vitro	Inosine is a nucleoside that is formed when hypoxanthine is attached to a ribose ring (also known as a ribofuranose) via a β-N9-glycosidic bond. This compound is commonly found in tRNAs and is essential for proper translation of the genetic code in wobble base pairs. Knowledge of its metabolism has led to advances in immunotherapy in recent decades. Its monophosphate is oxidised by the enzyme inosine monophosphate dehydrogenase, yielding xanthosine monophosphate, a key precursor in purine metabolism.
In vivo	LD50: Mice >6g/kg (i.g.)
References	[1] https://pubmed.ncbi.nlm.nih.gov/13115426/ [2] https://pubmed.ncbi.nlm.nih.gov/3693425/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2022-05-05)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04890808	NOT_YET_RECRUITING	Superficial Siderosis	Superficial Siderosis Research Alliance Inc.	2023-05
NCT07170475	RECRUITING	Parkinson's Disease (PD)	Fujita Health University	2025-06-27	PHASE1
NCT06355024	COMPLETED	Triple-negative Breast Cancer	Fudan University	2024-05-11	PHASE2
NCT05935787	COMPLETED	Stroke	POLYSAN Scientific & Technological Pharmaceutical Company	2023-06-30	PHASE3
NCT04631484	COMPLETED	Head Trauma,Closed	POLYSAN Scientific & Technological Pharmaceutical Company	2020-11-22	PHASE3
NCT04476238	COMPLETED	Healthy Volunteers	University Hospital, Basel, Switzerland	2022-02-28

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Inosine

Chemical Structure

Molecular Weight: 268.23