Inosine

Catalog No.S2442 Synonyms: NSC 20262, INO 495

For research use only.

Inosine (NSC 20262, INO 495) is a nucleoside that is formed when hypoxanthine is attached to a ribose ring via a β-N9-glycosidic bond.

Inosine Chemical Structure

CAS No. 58-63-9

Selleck's Inosine has been cited by 2 Publications

Purity & Quality Control

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Biological Activity

Description Inosine (NSC 20262, INO 495) is a nucleoside that is formed when hypoxanthine is attached to a ribose ring via a β-N9-glycosidic bond.
In vitro

Inosine is a nucleoside that is formed when hypoxanthine is attached to a ribose ring (also known as a ribofuranose) via a β-N9-glycosidic bond. Inosine is commonly found in tRNAs and is essential for proper translation of the genetic code in wobble base pairs. Knowledge of inosine metabolism has led to advances in immunotherapy in recent decades. Inosine monophosphate is oxidised by the enzyme inosine monophosphate dehydrogenase, yielding xanthosine monophosphate, a key precursor in purine metabolism. [1] [2]

In vivo LD50: Mice >6g/kg (i.g.) [3]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 53 mg/mL warmed
(197.59 mM)
Water 47 mg/mL warmed
(175.22 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 268.23
Formula

C10H12N4O5

CAS No. 58-63-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)CO)O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04476238 Not yet recruiting Dietary Supplement: Inosine|Other: Placebo Healthy Volunteers University Hospital Basel Switzerland February 2022 Not Applicable
NCT01726400 Completed Drug: Pegylated interferon alpha|Drug: Ribavirin Hepatitis C Fremantle Hospital and Health Service December 2012 --
NCT01675427 Completed Other: Interleukin 28B testing Hepatitis C Chronic Hoffmann-La Roche August 2011 Phase 4
NCT01639534 Completed -- Identify the Presence of a Marker of Ischemia/Hypoperfusion of the Brain Via Peripheral Blood|Ischemia/Hypoperfusion of Brain Virginia Commonwealth University March 2011 --
NCT00978965 Completed Genetic: MPA SNP Renal Transplantation Medical University of Vienna|Novartis October 2009 --
NCT00923728 Withdrawn Drug: AVN944 Refractory Solid Tumors Vertex Pharmaceuticals Incorporated|National Cancer Institute (NCI) April 2009 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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