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Mangiferin Nrf2 activator

Cat.No.S3808

Mangiferin (Alpizarin, Chinomin, Hedysarid) is a bioactive compound that demonstrates many health perspectives and has been used to prepare medicinal and food supplements. This compound is a Nrf2 activator. It suppresses nuclear translocation of the NF-κB subunits p65 and p50.
Mangiferin Nrf2 activator Chemical Structure

Chemical Structure

Molecular Weight: 422.34

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Quality Control

Batch: Purity: 99.99%
99.99

Solubility

In vitro
Batch:

DMSO : 89 mg/mL (210.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 422.34 Formula

C19H18O11

 Storage (From the date of receipt)
CAS No. 4773-96-0 Download SDF Storage of Stock Solutions

Synonyms Alpizarin, Chinomin, Hedysarid Smiles C1=C2C(=CC(=C1O)O)OC3=C(C2=O)C(=C(C(=C3)O)C4C(C(C(C(O4)CO)O)O)O)O

Mechanism of Action

Targets/IC50/Ki
Nrf2
NF-κB
In vitro

Mangiferin possesses several health endorsing properties such as antioxidant, antimicrobial, antidiabetic, antiallergic, anticancer, hypocholesterolemic, and immunomodulatory effects. It suppresses the activation of peroxisome proliferator activated receptor isoforms by changing the transcription process. This compound protects against different human cancers, including lung, colon, breast, and neuronal cancers, through the suppression of tumor necrosis factor α expression, inducible nitric oxide synthase potential, and proliferation and induction of apoptosis. It also protects against neural and breast cancers by suppressing the expression of matrix metalloproteinase (MMP)-9 and MMP-7 and inhibiting enzymatic activity, metastatic potential, and activation of the β-catenin pathway. It has the capacity to block lipid peroxidation, providing a shielding effect against physiological threats. Additionally, this chemical enhances the capacity of the monocyte-macrophage system and possesses antibacterial activity against gram-positive and gram-negative bacteria. It exerts a pro-hypoglycemic role by modulating glucose metabolism, ameliorating insulin resistance, lowering cholesterol synthesis, and inhibiting the expression of the tumor necrosis factor α and inducible nitric oxide synthase. It also induces apoptosis and inhibits the progression and promotion of cell proliferation by interfering with cell cycle regulation, the signaling of several cancer transduction pathways in tumor cells.
In vivo

Mangiferin can pass through the blood-ocular barrier and has been shown to be effective in curtailing various eye diseases. Administration of this compound (100 mg/kg BW) dissolved in corn oil in healthy male Swiss albino mice lowers the activity of lysosomal enzymes such as β-glucuronidase, acidphosphatase, β-galactosidase and N-acetyl glucosaminidase. Oral administration of this compound (100 miligram/kilogram BW) through the diet for 18 weeks significantly ameliorates the elevated levels of glycoprotein components, membrane lipid peroxidation, and ATPases in lung carcinoma-induced animals. It also ameliorates intestinal inflammation and impairs the gastrointestinal transit postoperative ileus (POI) of rats. This compound recovers delayed intestinal transit induced by intestinal manipulation. In mice, it shows a gastroprotective effect. Administration of this chemical (3, 10 and 30 mg/kg) decreases ethanol-induced gastric damage by 30, 35 and 63% respectively, and reduced indomethacin-induced gastric damage by 22, 23, and 57% respectively. In pylorus-ligated rats, gastric secretion and total acidity significantly decrease by this compound, and it effectively prevents the depletion of the ethanol-related protein from the gastric mucosa of the non-protein sulfhydryl content. This chemical exhibits an antidiabetic role in adult C57BL/6 J mice. It has a significant role in the reduction of cholesterol, triglycerides, and free fatty acid (FFA) levels in both serum and heart, and can also enhance heart tissue phospholipid levels in isoproterenol-induced cardiotoxic rats. This compound has a cytotoprotective role against the neurotoxicity and cognitive impairment induced by aluminium chloride in male Swiss albino mice.
References
  • [4] https://pubmed.ncbi.nlm.nih.gov/25739392/

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