Diosmetin

Catalog No.S2380 Synonyms: Luteolin 4-methyl ether

Diosmetin Chemical Structure

Molecular Weight(MW): 300.26

Diosmetin is a bioflavonoid found in spearmint, oregano, and many other plants.

Size Price Stock Quantity  
In DMSO USD 70 In stock
USD 50 In stock
USD 70 In stock
USD 170 In stock
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Purity & Quality Control

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Biological Activity

Description Diosmetin is a bioflavonoid found in spearmint, oregano, and many other plants.
Targets
CYP1A1 [1]
In vitro

Diosmetin inhibits 3H-dopamine uptake in neuroblastoma cells, as well as in small-cell lung carcinoma cells, which is be responsible for the increased vascular tone observed in vivo after treatment with Diosmetin. [1] Moreover, Diosmetin also removes iron from iron-loaded hepatocytes revealed a good relationship between this iron-chelating ability and the cytoprotective effect. [2] Other studies proves that Diosmetin is a cytochrome P450 inhibitor, thus inhibiting carcinogen activation and and causing pharmacokinetic interactions with co-administered drugs metabolized. [3] [4]

Protocol

Solubility (25°C)

In vitro DMSO 60 mg/mL (199.82 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 300.26
Formula

C16H12O6

CAS No. 520-34-3
Storage powder
in solvent
Synonyms Luteolin 4-methyl ether

Bio Calculators

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Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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P450 (e.g. CYP17) Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID