Epigenetics Compound Library

Catalog No.L1900

Offered in 96 or 384 well plate format

A unique collection of 580 compounds with biological activity used for epigenetic research and associated assays.

Size

Price

Pre-dissolved In DMSO or Water
100uL/well (2mM or 10mM solution)	USD 15720
2x100uL/well (2mM or 10mM solution)	USD 27576

Selleck USA Tel: (832) 582-8158 [email protected]

Selleck Chemicals compound library contributes and expedites
the investigation of treatments against COVID19

The researchers at the National Institute of Infectious Diseases, in Japan, successfully found anti-COVID19 drugs within 3 months of
screening FDA-approved drug library from Selleck Chemicals. They have already published this article doi: 10.1101/2020.04.14.039925.

Recently the accomplishment of this research, using Selleck Chemicals library, was reported on Japanese television

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Specific Compounds Quantities Plate Map Dry/solid or DMSO solution

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Epigenetics Compound Library Contents

Download the Epigenetics Compound Library - SDF

Download the Epigenetics Compound Library - XLSX

Cited by 56 Publications

Nat Med,2017,23(4):405-408

PubMed: 28388612 ( click the link to review the publication )

Nat Med,2014,20(8):954-60

PubMed: 24997607 ( click the link to review the publication )

Stem Cell Reports,2020,14(3):478-492

PubMed: 32084387 ( click the link to review the publication )

Cancer Lett,2020,469:195-206

PubMed: 31672491 ( click the link to review the publication )

PLoS One,2020,15(1):e0228189

PubMed: 31999754 ( click the link to review the publication )

Blood,2019,10.1182/blood.2019000015

PubMed: 31492675 ( click the link to review the publication )

Genome Biol,2019,20(1):253

PubMed: 31771620 ( click the link to review the publication )

Sci Adv,2019,5(6):eaav9784

PubMed: 31249867 ( click the link to review the publication )

Neuropsychopharmacology,2019,10.1038/s41386-018-0266-7

PubMed: 30518933 ( click the link to review the publication )

Antioxid Redox Signal,2019,28(13):1224-1237

PubMed: 29113455 ( click the link to review the publication )

Breast Cancer Res,2019,21(1):37

PubMed: 30845991 ( click the link to review the publication )

Signal Transduct Target Ther,2019,0.17430555556

PubMed: 31044091 ( click the link to review the publication )

Neurobiol Aging,2019,76:24-34

PubMed: 30640040 ( click the link to review the publication )

Cancer Gene Ther,2019,10.1038/s41417-019-0127-5

PubMed: 31383953 ( click the link to review the publication )

Stem Cells Int,2019,2019:3435901

PubMed: 31871467 ( click the link to review the publication )

Cancer Manag Res,2019,11:8391-8405

PubMed: 31571995 ( click the link to review the publication )

Breast Cancer Res Treat,2019,10.1007/s10549-019-05504-5

PubMed: 31784862 ( click the link to review the publication )

Acta Pharmacol Sin,2019,10.1038/s41401-019-0246-4

PubMed: 31197246 ( click the link to review the publication )

Cell Signal,2019,67:109508

PubMed: 31866490 ( click the link to review the publication )

Virology,2019,541:41-51

PubMed: 31826845 ( click the link to review the publication )

OMICS,2019,23(10):486-495

PubMed: 31549911 ( click the link to review the publication )

Bioengineered,2019,10(1):98-107

PubMed: 31023186 ( click the link to review the publication )

Kaohsiung J Med Sci,2019,10.1002/kjm2.12051

PubMed: 30896891 ( click the link to review the publication )

Nat Commun,2018,9(1):3212

PubMed: 30097580 ( click the link to review the publication )
Nat Commun,2018,9(1):1655

PubMed: 29695808 ( click the link to review the publication )

Cell Rep,2018,22(5):1185-1199

PubMed: 29386107 ( click the link to review the publication )

Redox Biology,2018,17:101076

PubMed: 30642723 ( click the link to review the publication )

Oncogene,2018,37(49):6341-6356

PubMed: 30042414 ( click the link to review the publication )

Cancer Lett,2018,436:28-37

PubMed: 30118842 ( click the link to review the publication )

Cancer Sci,2018,109(4):1220-1229

PubMed: 29453896 ( click the link to review the publication )

Sci Rep,2018,8(1):13106

PubMed: 30166612 ( click the link to review the publication )

J Cell Physiol,2018,233(1):422-433

PubMed: 28294327 ( click the link to review the publication )

Oncotarget,2018,9(57):31018-31031

PubMed: 30123424 ( click the link to review the publication )

Nat Commun,2017,8:15045

PubMed: 28429794 ( click the link to review the publication )

Anal Chem,2017,89(12):6678-6685

PubMed: 28520400 ( click the link to review the publication )

Stem Cells,2017,35(1):158-169

PubMed: 27422057 ( click the link to review the publication )

Antimicrob Agents Chemother,2017,62(1)

PubMed: 29061736 ( click the link to review the publication )

Skelet Muscle,2017,7(1):16

PubMed: 28870238 ( click the link to review the publication )

Stem Cells Transl Med,2016,5(8):1036-47

PubMed: 27194745 ( click the link to review the publication )

Pharmacol Res,2016,113(Pt A):216-227

PubMed: 27543462 ( click the link to review the publication )

PLoS One,2016,11(2):e0149848

PubMed: 26919709 ( click the link to review the publication )

Sensors (Basel),2016,16(3)

PubMed: 26999137 ( click the link to review the publication )

Nat Cell Biol,2015,17(1):57-67

PubMed: 25487280 ( click the link to review the publication )

Clin Cancer Res,2015,21(5):1172-82

PubMed: 25549722 ( click the link to review the publication )

Biosens Bioelectron,2015,68:699-704

PubMed: 25668591 ( click the link to review the publication )

Mol Cancer Ther,2015,14(5):1213-23

PubMed: 25777964 ( click the link to review the publication )

Virology,2015,482:244-259

PubMed: 25900886 ( click the link to review the publication )

Cell Cycle,2015,14(1):109-22

PubMed: 25602521 ( click the link to review the publication )
PLoS One,2015,10(11):e0142655

PubMed: 26569102 ( click the link to review the publication )

Oncotarget,2015,6(3):1531-43

PubMed: 25605238 ( click the link to review the publication )

Head Neck,2015,37(12):1722-32

PubMed: 24986420 ( click the link to review the publication )

Mol Cancer Res,2014,12(5):703-13

PubMed: 24554781 ( click the link to review the publication )

Oncotarget,2014,5(15):6512-25

PubMed: 25156567 ( click the link to review the publication )

Curr Protoc Chem Biol,2014,4:177-191

PubMed: 26705509 ( click the link to review the publication )

Case Studies using Selleck Compound Libraries

Application of GPCR Compound Library in liver cancer (This article was published in Nature (IF=43) and took about 15 months):
Nature.2019;574(7777):268-272
Application of Kinase Inhibitor Library in colorectal cancer (This article was published in Nature Communications (IF=11) and took about 8 months):
Nat Commun. 2019 16;10(1):2197
Application of FDA-approved Drug Library in antivirus (This article was published in Cell Research (IF=17) and took about 13 months):
Cell Res. 2019;29(9):739-753
Application of FDA-approved Drug Library in metabolism (This article was published in Movement Disorders (IF=8) and took about 10 months):
Mov Disord. 2019;34(3):323-334
Application of Epigenetics Compound Library in acute lymphoblastic leukemia (This article was published in Blood (IF=16) and took about 16 months):
Blood. 2019 17;134(16):1323-1336
Application of Inhibitor Library in tumor immunology (This article was published in Cancer Immunol Res (IF=8.6) and took about 12 months):
Cancer Immunol Res.2017;5(9):790-803

Description & Advantages

•A unique collection of 580 compounds with biological activity used for epigenetics research and associated assays

•A valuable tool for chemical genomics, epigenetic target identification in pharmacogenomics, and other biological applications

• This library contains inhibitors of epigenetic enzymes including Histone Deacetylase (HDACs), SIRTs, Lysine demethylases, Histone Acetyltransferases (HATs), DNA Methyltransferase (Dnmts), and SIRTs activators

• Structurally diverse, medicinally active, and cell permeable

• Rich documentation with structure and customer reviews

• NMR and HPLC validated to ensure the highest purity

Product Details

Formulation:	556 compounds pre-dissolved in 10mM DMSO, 10 compounds pre-dissolved in 10mM water, 12 compounds pre-dissolved in 2mM DMSO and 2 compounds pre-dissolved in 2mM water
Container:	96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Stability:	12 months -20°C in DMSO
Stability:	24 months -80°C in DMSO
Shipping:	Blue ice or dry ice
Packaging:	Inert gas

Epigenetics Compound Library Composition

HTS Facility Partners

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