Home Immunology & Inflammation Immunology & Inflammation related chemical Ligustrazine hydrochloride

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Ligustrazine hydrochloride Immunology & Inflammation related chemical

Cat.No.S3775

Ligustrazine hydrochloride (Tetramethylpyrazine, Tetrapyrazine) is a chemical compound found in natto and in fermented cocoa beans with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.
Ligustrazine hydrochloride Immunology & Inflammation related chemical Chemical Structure

Chemical Structure

Molecular Weight: 172.66

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Quality Control

Batch: S377501 DMSO]34 mg/mL]false]]]false]]]false Purity: 99.65%
99.65

Solubility

In vitro
Batch:

DMSO : 34 mg/mL (196.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Chemical Information, Storage & Stability

Molecular Weight 172.66 Formula

C8H12N2.HCl

 Storage (From the date of receipt)
CAS No. 76494-51-4 Download SDF Storage of Stock Solutions

Synonyms Tetramethylpyrazine HCl, Tetrapyrazine HCl Smiles CC1=C(N=C(C(=N1)C)C)C.Cl

Mechanism of Action

In vitro
Tetramethylpyrazine (TMP) is described as "calcium antagonist" and produces a vasodilation effect via inhibiting Ca2+ influx and the release of intracellular Ca2+ at first. TMP can affect the calcium influx, at least partly, by mediating the opening of potassium channel. TMP is also reported to have a direct effect on L-type calcium current, since it can reduce calcium transient in a dose-dependent manner when applied to rabbit ventricular myocyte. TMP also exerts an endothelium protective property via downregulating the expression of ICAM-1 and HSP60. TMP can restrain LPS-induced IL-8 overexpression in HUVECs at both the protein and mRNA levels, which is possibly due to blocking the activation of the NF-kB-dependent pathway; the involvement of ERK and p38 MAPK signaling pathway has also been observed.
In vivo
Tetramethylpyrazine (TMP) can stimulate NO production in pulmonary arteries of rat. Akt and the endothelial isoform of nitric oxide synthase (eNOS) phosphorylation were significantly upregulated after TMP pretreatment in vivo. TMP can suppress the proliferation of VSMC in rabbit aortic vascular. TMP can decrease the ANP mRNA expression in cardiomyocyte hypertrophy rat model and suppress the level of pJAK2, pJAK1, or pSTAT3, demonstrating that TMP can inhibit JAK-STAT signal transduction. It has a short in-vivo half-life (T1/2=2.89 h).
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