Ligustrazine hydrochloride

Catalog No.S3775 Synonyms: Tetramethylpyrazine HCl, Tetrapyrazine HCl

Ligustrazine hydrochloride Chemical Structure

Molecular Weight(MW): 172.66

Tetramethylpyrazine, also known as ligustrazine, is a chemical compound found in natto and in fermented cocoa beans with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.

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Biological Activity

Description Tetramethylpyrazine, also known as ligustrazine, is a chemical compound found in natto and in fermented cocoa beans with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.
In vitro

Tetramethylpyrazine (TMP) is described as "calcium antagonist" and produces a vasodilation effect via inhibiting Ca2+ influx and the release of intracellular Ca2+ at first. TMP can affect the calcium influx, at least partly, by mediating the opening of potassium channel. TMP is also reported to have a direct effect on L-type calcium current, since it can reduce calcium transient in a dose-dependent manner when applied to rabbit ventricular myocyte. TMP also exerts an endothelium protective property via downregulating the expression of ICAM-1 and HSP60. TMP can restrain LPS-induced IL-8 overexpression in HUVECs at both the protein and mRNA levels, which is possibly due to blocking the activation of the NF-kB-dependent pathway; the involvement of ERK and p38 MAPK signaling pathway has also been observed[1].

In vivo Tetramethylpyrazine (TMP) can stimulate NO production in pulmonary arteries of rat. Akt and the endothelial isoform of nitric oxide synthase (eNOS) phosphorylation were significantly upregulated after TMP pretreatment in vivo. TMP can suppress the proliferation of VSMC in rabbit aortic vascular. TMP can decrease the ANP mRNA expression in cardiomyocyte hypertrophy rat model and suppress the level of pJAK2, pJAK1, or pSTAT3, demonstrating that TMP can inhibit JAK-STAT signal transduction. It has a short in-vivo half-life (T1/2=2.89 h)[1].

Protocol

Cell Research:

[3]

+ Expand
  • Cell lines: HL-60 cells
  • Concentrations: 300 µg/mL
  • Incubation Time: 24, 48, 60, 72 h
  • Method:

    Cell viability is determined by the MTT assay. HL-60 cells are treated with 300 µg/mL TMP, 0.5 µM As2O3, and 300 µg/mL TMP combined with 0.5 µM As2O3, respectively.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: A rat model of Parkinson
  • Formulation: 3% DMSO
  • Dosages: 20 mg/kg/d
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 34 mg/mL (196.91 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 172.66
Formula

C8H12N2.HCl

CAS No. 76494-51-4
Storage powder
in solvent
Synonyms Tetramethylpyrazine HCl, Tetrapyrazine HCl

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID