Gambogenic acid

Catalog No.S9031

For research use only.

Gambogenic Acid, identified from Gamboge, is an inhibitor of the FGFR signaling pathway in erlotinib-resistant non-small-cell lung cancer (NSCLC) and exhibits anti-tumor effects. Gambogenic acid acts is also an effective inhibitor of EZH2 that specifically and covalently binds to Cys668 within the EZH2-SET domain, and triggers EZH2 ubiquitination.

Gambogenic acid Chemical Structure

CAS No. 173932-75-7

Selleck's Gambogenic acid has been cited by 2 Publications

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Biological Activity

Description Gambogenic Acid, identified from Gamboge, is an inhibitor of the FGFR signaling pathway in erlotinib-resistant non-small-cell lung cancer (NSCLC) and exhibits anti-tumor effects. Gambogenic acid acts is also an effective inhibitor of EZH2 that specifically and covalently binds to Cys668 within the EZH2-SET domain, and triggers EZH2 ubiquitination.
Targets
FGFR [1] EZH2 [2]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 630.77
Formula

C38H46O8

CAS No. 173932-75-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(=CCCC(=CCC1=C(C(=C2C(=C1O)C(=O)C3=CC4CC5C3(O2)C(C4=O)(OC5(C)C)CC=C(C)C(=O)O)CC=C(C)C)O)C)C

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05179174 Recruiting Genetic: blood sample examination Uveal Melanoma University of Catania April 20 2021 --
NCT03838913 Unknown status -- Bile Duct Neoplasms|Intraductal Papillary Mucinous Neoplasm Fujian Provincial Hospital|Fujian Medical University Union Hospital|First Affiliated Hospital of Fujian Medical University February 15 2019 --
NCT03671525 Suspended Drug: Nimodipine|Drug: Placebo oral capsule Schizophrenia|Schizo Affective Disorder Johns Hopkins University October 5 2018 Early Phase 1
NCT02849145 Completed Biological: Blood sampling Uveal Melanoma Institut Curie September 2014 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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