Home TGF-beta/Smad PKC inhibitor Myricitrin

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Myricitrin PKC inhibitor

Cat.No.S2327

Myricitrin (Myricitrine), a flavonoid compound isolated from the root bark of Myrica cerifera, which exerts antinociceptive effects.
Myricitrin PKC inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 464.38

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Quality Control

Batch: S232701 DMSO]93 mg/mL]false]Ethanol]1 mg/mL]false]Water]Insoluble]false Purity: 99.77%
99.77

Solubility

In vitro
Batch:

DMSO : 93 mg/mL (200.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 1 mg/mL

Water : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 464.38 Formula

C21H20O12

 Storage (From the date of receipt)
CAS No. 17912-87-7 Download SDF Storage of Stock Solutions

Synonyms Myricitrine Smiles CC1C(C(C(C(O1)OC2=C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC(=C(C(=C4)O)O)O)O)O)O

Mechanism of Action

Targets/IC50/Ki
PKCα
PKCε
In vitro
Myricitrin, a flavonoid compound isolated from the root bark of Myrica cerifera, which exerts antinociceptive effect. This compound produces pronounced antinociception against chemical and mechanical models of pain in rodents via preventing the protein kinase C (PKC) alpha and PKC epsilon activation by phorbol myristate acetate (PMA). Another study proves that opening of voltage- and small-conductance calcium-gated K(+) channels and reduction of calcium influx leads to the antinociceptive of this compound. It also decreases H2O2-induced apoptosis in vascular endothelial cells via inhibition of p53 gene expression, activation of caspase-3 and the MAPK signaling pathway, and alteration of the patterns of pro-apoptotic and anti-apoptotic gene expression.
In vivo
In mice, myricitrin (i.p. 10 mg/kg or 30 mg/kg) blocks apomorphine-induced stereotypy and climbing, and increases hindlimb retraction time (HRT).
References
  • [4] https://pubmed.ncbi.nlm.nih.gov/21689712/

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