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Dehydroabietic acid Anti-infection inhibitor

Name: Dehydroabietic acid
Brand: Selleck Chemicals
SKU: S3226
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S3226

Dehydroabietic acid (DAA, DHAA), a naturally occurring diterpene resin acid derived from coniferous plants such as Pinus and Picea, displays anti-inflammatory activity via suppression of Src-, Syk-, and TAK1-mediated pathways.

Chemical Structure

Molecular Weight: 300.44

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Quality Control

Batch: S322601 DMSO]100 mg/mL]false]]]false]]]false Purity: 99.45%

Cited in Nature Medicine for its top-tier quality
COA
SDS
Datasheet

99.45

Related Targets	PD-1/PD-L1 CXCR STING AhR Immunology & Inflammation related CD markers Interleukins Antioxidant COX Histamine Receptor
Other Anti-infection Inhibitors	Clorsulon Sodium Tauroursodeoxycholate (TUDC) Cinchonidine Berberine chloride hydrate Chlorquinaldol p-Coumaric Acid Ascomycin (FK520) LL37 (Human cathelicidin) Cetrimonium Bromide (CTAB) Nitidine Chloride

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (332.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	300.44	Formula	C₂₀H₂₈O₂	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	1740-19-8	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	DAA, DHAA			Smiles	CC(C)C1=CC2=C(C=C1)C3(C)CCCC(C)(C3CC2)C(O)=O

Mechanism of Action

Targets/IC₅₀/Ki	Src Syk TAK1
References	[1] https://pubmed.ncbi.nlm.nih.gov/30934981/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05506475	Not yet recruiting	HIV Infection\|Hepatitis C Infection	Institut Pasteur\|National Institute of Hygiene and Epidemiology Vietnam\|ANRS Emerging Infectious Diseases	May 2024	--
NCT05521880	Not yet recruiting	Substance Use Disorders\|Infection Soft Tissue\|Bacteremia\|Osteomyelitis Acute\|Septic Arthritis	University of Maryland Baltimore	May 2024	Phase 4
NCT05992077	Recruiting	HCV Infection	ANRS Emerging Infectious Diseases	August 7 2023	Not Applicable
NCT05713136	Not yet recruiting	Hepatitis C	Kirby Institute	August 14 2023	--
NCT05248555	Recruiting	Hepatitis C	Kirby Institute	January 16 2023	--

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Handling Instructions

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