Home Transmembrane Transporters TRP Channel agonist Methyl salicylate For research use only.

Methyl salicylate

Synonyms: 2-Carbomethoxyphenol, Betula oil, Gaultheria oil, Methyl 2-hydroxybenzoate, Natural wintergreen oil

Methyl salicylate (Betula oil, Gaultheria oil, Methyl 2-hydroxybenzoate, Natural wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. It is an agonist for TRPA1 and TRPV1.

Methyl salicylate Chemical Structure

Methyl salicylate Chemical Structure

CAS: 119-36-8

Purity & Quality Control

Batch: S375601 Purity: 98%
98

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Biological Activity

Description Methyl salicylate (Betula oil, Gaultheria oil, Methyl 2-hydroxybenzoate, Natural wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. It is an agonist for TRPA1 and TRPV1.
Targets
TRPA1 [1]
(Cell-free assay)		 TRPV1 [1]
(Cell-free assay)
In vitro
In vitro In human embryonic kidney 293 cells expressing human TRPV1 (hTRPV1), Methyl salicylate evokes increases of [Ca2+]i, which declines regardless of its continuous presence, indicative of marked desensitization. Methyl salicylate promotes Ca2+ influx through the activation of TRPV1 channels and reversibly inhibits hTRPV1 activation by polymodal stimuli such as capsaicin, protons, heat, anandamide, and 2-aminoethoxydiphenyl borate. Methyl salicylate is an effective agonist for recombinant human and porcine TRPV1[1].
Cell Research Cell lines HEK 293 cells
Concentrations 3 mM
Incubation Time --
Method Fura-2-loaded hTRPV1-expressing HEK 293 cells are first stimulated with capsaicin (30 nM) and subsequently with Methyl salicylate (3 mM).
In Vivo
In vivo Methyl salicylate significantly suppresses nocifensive behavior induced by intraplantar capsaicin in rats[1].
Animal Research Animal Models Male Wistar rats (8 weeks old)
Dosages 0.5 mg
Administration injected into the same hind paw

Chemical Information & Solubility

Molecular Weight 152.15 Formula

C8H8O3
CAS No. 119-36-8 SDF Download Methyl salicylate SDF Download Methyl salicylate SDF
Density 1.174 g/mL at 25 °C
Smiles COC(=O)C1=CC=CC=C1O
Storage (From the date of receipt) 2 years -80°C liquid

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