Methyl salicylate

For research use only.

Catalog No.S3756 Synonyms: 2-Carbomethoxyphenol, Betula oil, Gaultheria oil, Methyl 2-hydroxybenzoate, Natural wintergreen oil

Methyl salicylate Chemical Structure

Molecular Weight(MW): 152.15

Methyl salicylate is an organic ester naturally produced by many species of plants, particularly wintergreens. It is an agonist for TRPA1 and TRPV1.

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Biological Activity

Description Methyl salicylate is an organic ester naturally produced by many species of plants, particularly wintergreens. It is an agonist for TRPA1 and TRPV1.
Targets
TRPA1 [1]
(Cell-free assay)
TRPV1 [1]
(Cell-free assay)
In vitro

In human embryonic kidney 293 cells expressing human TRPV1 (hTRPV1), Methyl salicylate evokes increases of [Ca2+]i, which declines regardless of its continuous presence, indicative of marked desensitization. Methyl salicylate promotes Ca2+ influx through the activation of TRPV1 channels and reversibly inhibits hTRPV1 activation by polymodal stimuli such as capsaicin, protons, heat, anandamide, and 2-aminoethoxydiphenyl borate. Methyl salicylate is an effective agonist for recombinant human and porcine TRPV1[1].

In vivo Methyl salicylate significantly suppresses nocifensive behavior induced by intraplantar capsaicin in rats[1].

Protocol

Cell Research:[1]
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  • Cell lines: HEK 293 cells
  • Concentrations: 3 mM
  • Incubation Time: --
  • Method: Fura-2-loaded hTRPV1-expressing HEK 293 cells are first stimulated with capsaicin (30 nM) and subsequently with Methyl salicylate (3 mM).
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Male Wistar rats (8 weeks old)
  • Dosages: 0.5 mg
  • Administration: injected into the same hind paw
    (Only for Reference)

Solubility (25°C)

Chemical Information

Molecular Weight 152.15
Formula

C8H8O3

CAS No. 119-36-8
Storage powder
in solvent
Synonyms 2-Carbomethoxyphenol, Betula oil, Gaultheria oil, Methyl 2-hydroxybenzoate, Natural wintergreen oil
Smiles COC(=O)C1=C(O)C=CC=C1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID