Home Immunology & Inflammation ROS inhibitor Dehydroevodiamine

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Dehydroevodiamine ROS inhibitor

Cat.No.S3816

Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities. This compound inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells.
Dehydroevodiamine ROS inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 301.34

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Quality Control

Batch: S381601 DMSO]19 mg/mL]false]]]false]]]false Purity: 99.72%
99.72

Solubility

In vitro
Batch:

DMSO : 19 mg/mL (63.05 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Chemical Information, Storage & Stability

Molecular Weight 301.34 Formula

C19H15N3O

 Storage (From the date of receipt)
CAS No. 67909-49-3 Download SDF Storage of Stock Solutions

Synonyms DHED Smiles CN1C2=CC=CC=C2C(=O)N3C1=C4C(=C5C=CC=CC5=N4)CC3

Mechanism of Action

Targets/IC50/Ki
NF-κB
COX-2
iNOS
PGE2
In vivo

The dose ranging study demonstrated that the volume of distribution and clearance are independent of the dose. The primary route of elimination for the drug is via metabolism. i.v. administration of this compound elicited a slight but significant reduction in blood pressure and a marked decrease in heart rate.
References
  • [4] https://pubmed.ncbi.nlm.nih.gov/16554073/

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