Methyl syringate

Catalog No.S4787 Synonyms: Syringic Acid Methyl Ester

Methyl syringate Chemical Structure

Molecular Weight(MW): 212.20

Methyl syringate, a plant phenolic compound, is a specific and selective TRPA1 agonist.

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Biological Activity

Description Methyl syringate, a plant phenolic compound, is a specific and selective TRPA1 agonist.
Targets
TRPA1 [1]
()
In vitro

Methyl syringate increases cytosolic Ca2+ in human TRPA1 (hTRPA1)-transfected cells[1]. Methyl syringate selectively activated hTRPA1 (EC(50) = 507.4 μM), but not hTRPV1[2].

In vivo Methyl syringate regulates food intake and gastric emptying through a TRPA1-mediated pathway and, by extension, can contribute to weight suppression in ICR mice[1].

Protocol

Animal Research:[1]
+ Expand
  • Animal Models: Male ICR mice
  • Formulation: 1.5% methylcellulose
  • Dosages: 10 mg/kg
  • Administration: by gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 42 mg/mL (197.92 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 212.20
Formula

C10H12O5

CAS No. 884-35-5
Storage powder
in solvent
Synonyms Syringic Acid Methyl Ester

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID