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Xanthurenic Acid GluR activator

Name: Xanthurenic Acid
Brand: Selleck Chemicals
SKU: S4774
Availability: InStock
Rating: 5 (2 reviews)

Cat.No.S4774

Xanthurenic acid (xanthurenate, 8-Hydroxykynurenic acid, 4,8-Dihydroxyquinaldic acid), a molecule arising from tryptophan metabolism by transamination of 3-hydroxykynurenine, activates mGlu2/3 Metabotropic glutamate receptors (mGlu2 and mGlu3).

Chemical Structure

Molecular Weight: 205.17

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Quality Control

Batch: S477401 DMSO]7 mg/mL]false]]]false]]]false Purity: 99.99%

Cited in Nature Medicine for its top-tier quality
COA
SDS
Datasheet

99.99

Related Targets	Adrenergic Receptor AChR 5-HT Receptor COX Calcium Channel Histamine Receptor Dopamine Receptor GABA Receptor TRP Channel Cholinesterase (ChE)
Other GluR Inhibitors	pomaglumetad (LY404039) (S)-Glutamic acid O-Phospho-L-serine CTEP (RO4956371) SIB 1757 L-Glutamic acid monosodium salt Capric acid VU 0357121 MPEP VU 0364439

Solubility

In vitro
Batch:

DMSO : 7 mg/mL (34.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Average weight of animals: g

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	205.17	Formula	C₁₀H₇NO₄	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	59-00-7	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	xanthurenate, 8-Hydroxykynurenic acid, 4,8-Dihydroxyquinaldic acid			Smiles	C1=CC2=C(C(=C1)O)NC(=CC2=O)C(=O)O

Mechanism of Action

Targets/IC₅₀/Ki	mGlu2 mGlu3
In vitro	Xanthurenic acid (XA) is considered as a putative neurotransmitter in the CNS, being stored in synaptic vesicles and released by membrane depolarization in a Ca2+-dependent fashion. It is known to inhibit vesicular glutamate transporters (VGLUTs). In heterologous expression systems, Xanthurenic acid could activate both mGlu2 and mGlu3 receptors with high potency, but has no activity on mGlu4 and mGlu7 receptors. Xanthurenic acid induces cell death associated with caspase-3, -8, and -9 activation, nuclear DNA cleavage, and cytochrome C release while not associated with cytoskeleton breakdown -- apoptosis induced by xanthurenic acid does not cause cytoskeleton depolymerization.
In vivo	Systemic administration of Xanthurenic acid in mice produces antipsychotic-like effects in the MK-801-induced model of hyperactivity and peripheral xanthurenic acid can cross the blood-brain barrier, influence the activity of brain regions that are involved in the pathophysiology of schizophrenia.
References	[1] https://www.nature.com/articles/srep17799 [2] https://pubmed.ncbi.nlm.nih.gov/11459518/

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