Caulophylline (N-Methylcytisine)

For research use only.

Catalog No.S3298 Synonyms: Caulophyllin, NMC

Caulophylline (N-Methylcytisine) Chemical Structure

CAS No. 486-86-2 (63699-79-6, 207-643-8)

Caulophylline (N-Methylcytisine, Caulophyllin, NMC) is a tricyclic quinolizidine alkaloid with anti-inflammatory activities. Caulophylline binds to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia with Kd of 50 nM. Caulophylline significantly reduces myeloperoxidase (MPO) activity, blocks the activation of NF-κB by inhibiting IκB and IKK phosphorylation.

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Biological Activity

Description Caulophylline (N-Methylcytisine, Caulophyllin, NMC) is a tricyclic quinolizidine alkaloid with anti-inflammatory activities. Caulophylline binds to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia with Kd of 50 nM. Caulophylline significantly reduces myeloperoxidase (MPO) activity, blocks the activation of NF-κB by inhibiting IκB and IKK phosphorylation.
Targets
MPO [2]
()
IκB [2]
()
IKK [2]
()
NF-κB [2]
()
nAChR [1]
(Cell-free assay)
50 nM(Kd)

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (489.54 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 204.27
Formula

C12H16N2O

CAS No. 486-86-2 (63699-79-6, 207-643-8)
Storage powder
in solvent
Synonyms Caulophyllin, NMC

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04457765 Withdrawn Drug: Povidone-Iodine (PVP-I) Rhinoplasty Boston Medical Center April 2021 Early Phase 1
NCT04979013 Completed Other: Smoking Abstinence Smoking|Smoking Cessation|Tobacco Use RAI Services Company May 30 2019 Not Applicable
NCT02012699 Recruiting -- Pancreatic Cancer|Thyroid Cancer|Lung Cancer|Esophageal Cancer|Thymus Cancer|Colon Cancer|Rectal Cancer|GIST|Anal Cancer|Bile Duct Cancer|Duodenal Cancer|Gallbladder Cancer|Gastric Cancer|Liver Cancer|Small Intestine Cancer|Peritoneal Surface Malignancies|Familial Adenomatous Polyposis|Lynch Syndrome|Bladder Cancer|Kidney Cancer|Penile Cancer|Prostate Cancer|Testicular Cancer|Ureter Cancer|Urethral Cancer|Hypopharyngeal Cancer|Laryngeal Cancer|Lip Cancer|Oral Cavity Cancer|Nasopharyngeal Cancer|Oropharyngeal Cancer|Paranasal Sinus Cancer|Nasal Cavity Cancer|Salivary Gland Cancer|Skin Cancer|CNS Tumor|CNS Cancer|Mesothelioma|Breast Cancer|Leukemia|Melanoma|Sarcoma|Unknown Primary Tumor|Multiple Myeloma|Ovarian Cancer|Endometrial Cancer|Vaginal Cancer|Neuroendocrine Tumors|Plasma Cell Dyscrasia|Healthy Control University of Nebraska November 2013 --
NCT01115335 Completed Procedure: Neonatal male circumcision Neonatal Male Circumcision University of Alabama at Birmingham|University Teaching Hospital Lusaka Zambia October 2009 Phase 4

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AChR Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID