Home Neuronal Signaling AChR antagonist - Peroxidases inhibitor - NF-κB inhibitor - IκB/IKK inhibitor Caulophylline (N-Methylcytisine) For research use only.

Caulophylline (N-Methylcytisine)

Synonyms: Caulophyllin, NMC

Caulophylline (N-Methylcytisine, Caulophyllin, NMC) is a tricyclic quinolizidine alkaloid with anti-inflammatory activities. Caulophylline binds to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia with Kd of 50 nM. Caulophylline significantly reduces myeloperoxidase (MPO) activity, blocks the activation of NF-κB by inhibiting IκB and IKK phosphorylation.

Caulophylline (N-Methylcytisine) Chemical Structure

Caulophylline (N-Methylcytisine) Chemical Structure

CAS: 486-86-2

Purity & Quality Control

Batch: S329801 DMSO] 100 mg/mL] false] ] ] false] ] ] false Purity: 99.85%
99.85

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Signaling Pathway

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Biological Activity

Description Caulophylline (N-Methylcytisine, Caulophyllin, NMC) is a tricyclic quinolizidine alkaloid with anti-inflammatory activities. Caulophylline binds to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia with Kd of 50 nM. Caulophylline significantly reduces myeloperoxidase (MPO) activity, blocks the activation of NF-κB by inhibiting IκB and IKK phosphorylation.
Targets
MPO [2] IκB [2] IKK [2] NF-κB [2] nAChR [1]
(Cell-free assay)
50 nM(Kd)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05689476 Recruiting
Work of Breathing|Lung Transplantation|Neurally Adjusted Ventilatory Assist|Ventilator-Induced Lung Injury
University of Padova
 December 27 2022 Not Applicable
NCT04457765 Withdrawn
Rhinoplasty
Boston Medical Center
 April 2021 Early Phase 1
NCT04979013 Completed
Smoking|Smoking Cessation|Tobacco Use
RAI Services Company
 May 30 2019 Not Applicable
NCT02012699 Recruiting
Pancreatic Cancer|Thyroid Cancer|Lung Cancer|Esophageal Cancer|Thymus Cancer|Colon Cancer|Rectal Cancer|GIST|Anal Cancer|Bile Duct Cancer|Duodenal Cancer|Gallbladder Cancer|Gastric Cancer|Liver Cancer|Small Intestine Cancer|Peritoneal Surface Malignancies|Familial Adenomatous Polyposis|Lynch Syndrome|Bladder Cancer|Kidney Cancer|Penile Cancer|Prostate Cancer|Testicular Cancer|Ureter Cancer|Urethral Cancer|Hypopharyngeal Cancer|Laryngeal Cancer|Lip Cancer|Oral Cavity Cancer|Nasopharyngeal Cancer|Oropharyngeal Cancer|Paranasal Sinus Cancer|Nasal Cavity Cancer|Salivary Gland Cancer|Skin Cancer|CNS Tumor|CNS Cancer|Mesothelioma|Breast Cancer|Leukemia|Melanoma|Sarcoma|Unknown Primary Tumor|Multiple Myeloma|Ovarian Cancer|Endometrial Cancer|Vaginal Cancer|Neuroendocrine Tumors|Plasma Cell Dyscrasia|Healthy Control
University of Nebraska
 November 1 2013 --
NCT01115335 Completed
Neonatal Male Circumcision
University of Alabama at Birmingham|University Teaching Hospital Lusaka Zambia
 October 2009 Phase 4

Chemical Information & Solubility

Molecular Weight 204.27 Formula

C12H16N2O
CAS No. 486-86-2 SDF --
Smiles CN1CC2CC(C1)C3=CC=CC(=O)N3C2
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (489.54 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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