Royal jelly acid

Catalog No.S3827 Synonyms: 10-Hydroxy-trans-2-decenoic acid, 10H2DA

For research use only.

Royal jelly acid (10-Hydroxy-trans-2-decenoic acid, 10H2DA) is the principal lipid component in royal jelly which is the food for queen and larvae honeybees. It is involved in several treatment processes of autoimmune and inflammatory diseases, including inhibition of lipopolysaccharide (LPS)- and interferon (IFN)-γ-stimulated macrophage responses, inhibition of T-cell proliferation and anti-rheumatoid activity.

Royal jelly acid Chemical Structure

CAS No. 14113-05-4

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Biological Activity

Description Royal jelly acid (10-Hydroxy-trans-2-decenoic acid, 10H2DA) is the principal lipid component in royal jelly which is the food for queen and larvae honeybees. It is involved in several treatment processes of autoimmune and inflammatory diseases, including inhibition of lipopolysaccharide (LPS)- and interferon (IFN)-γ-stimulated macrophage responses, inhibition of T-cell proliferation and anti-rheumatoid activity.
In vitro

Royal jelly acid (10H2DA) is a unique fatty acid found specifically in royal jelly and shows various pharmacological activities. With respect to inhibition of innate immune signals, however, 10H2DA shows a quite restricted effect which is dependent upon the stimulation[1].

In vivo The Royal jelly acid (10H2DA) concentration that can inhibit innate immune signals is more than a few millimolars, but reaching the effective concentration when administering to the gastrointestinal tract or skin is relatively easy[1].

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 186.25
Formula

C10H18O3

CAS No. 14113-05-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C(CCCC=CC(=O)O)CCCO

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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