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Royal jelly acid IFN inhibitor

Name: Royal jelly acid
Brand: Selleck Chemicals
SKU: S3827
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S3827

Royal jelly acid (10-Hydroxy-trans-2-decenoic acid, 10H2DA) is the principal lipid component in royal jelly which is the food for queen and larvae honeybees. It is involved in several treatment processes of autoimmune and inflammatory diseases, including inhibition of lipopolysaccharide (LPS)- and interferon (IFN)-γ-stimulated macrophage responses, inhibition of T-cell proliferation and anti-rheumatoid activity.

Chemical Structure

Molecular Weight: 186.25

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Quality Control

Batch: Purity: 100.00%

100.00

Related Targets	PD-1/PD-L1 CXCR STING AhR Immunology & Inflammation related CD markers Interleukins Anti-infection Antioxidant COX
Other IFN Inhibitors	Aloe-emodin KIN1148 IFN alpha-IFNAR-IN-1 hydrochloride Tilorone dihydrochloride 2',3'-cGAMP RO8191

Solubility

In vitro
Batch:

DMSO : 37 mg/mL (198.65 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 37 mg/mL

Water : 3 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	186.25	Formula	C₁₀H₁₈O₃	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	14113-05-4	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	10-Hydroxy-trans-2-decenoic acid, 10H2DA			Smiles	C(CCCC=CC(=O)O)CCCO

Mechanism of Action

In vitro	Royal jelly acid (10H2DA) is a unique fatty acid found specifically in royal jelly and shows various pharmacological activities. With respect to inhibition of innate immune signals, however, 10H2DA shows a quite restricted effect which is dependent upon the stimulation.
In vivo	The Royal jelly acid (10H2DA) concentration that can inhibit innate immune signals is more than a few millimolars, but reaching the effective concentration when administering to the gastrointestinal tract or skin is relatively easy.
References	[1] https://pubmed.ncbi.nlm.nih.gov/23061418/

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