Royal jelly acid

Catalog No.S3827 Synonyms: 10-Hydroxy-trans-2-decenoic acid, 10H2DA|

Royal jelly acid Chemical Structure

Molecular Weight(MW): 186.25

Royal jelly acid is the principal lipid component in royal jelly which is the food for queen and larvae honeybees. It is involved in several treatment processes of autoimmune and inflammatory diseases, including inhibition of lipopolysaccharide (LPS)- and interferon (IFN)-γ-stimulated macrophage responses, inhibition of T-cell proliferation and anti-rheumatoid activity.

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Biological Activity

Description Royal jelly acid is the principal lipid component in royal jelly which is the food for queen and larvae honeybees. It is involved in several treatment processes of autoimmune and inflammatory diseases, including inhibition of lipopolysaccharide (LPS)- and interferon (IFN)-γ-stimulated macrophage responses, inhibition of T-cell proliferation and anti-rheumatoid activity.
In vitro

Royal jelly acid (10H2DA) is a unique fatty acid found specifically in royal jelly and shows various pharmacological activities. With respect to inhibition of innate immune signals, however, 10H2DA shows a quite restricted effect which is dependent upon the stimulation[1].

In vivo The Royal jelly acid (10H2DA) concentration that can inhibit innate immune signals is more than a few millimolars, but reaching the effective concentration when administering to the gastrointestinal tract or skin is relatively easy[1].

Protocol

Solubility (25°C)

In vitro DMSO 37 mg/mL (198.65 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 186.25
Formula

C10H18O3

CAS No. 14113-05-4
Storage powder
in solvent
Synonyms 10-Hydroxy-trans-2-decenoic acid, 10H2DA|

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID