Urea

Catalog No.S3687 Synonyms: Carbonyldiamide, Ureophil

For research use only.

Urea (Carbonyldiamide, Ureophil) is a highly soluble organic compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.

Urea Chemical Structure

CAS No. 57-13-6

Selleck's Urea has been cited by 1 Publication

Purity & Quality Control

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Biological Activity

Description Urea (Carbonyldiamide, Ureophil) is a highly soluble organic compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 12 mg/mL
(199.8 mM)
Water 12 mg/mL
(199.8 mM)
Ethanol 12 mg/mL
(199.8 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 60.06
Formula

CH4N2O

CAS No. 57-13-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C(=O)(N)N

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04588207 Recruiting Drug: Urea Hyponatremia|Inappropriate ADH Syndrome Helbert Rondon Berrios MD MS|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|University of Pittsburgh February 2022 Phase 2
NCT04589065 Recruiting Device: Selective Cytopheretic Device Heart Failure|Chronic Systolic Heart Failure|Renal Failure|Cardiorenal Syndrome Keith Aaronson MD|University of Michigan January 2022 Not Applicable
NCT05108402 Not yet recruiting Diagnostic Test: Phenotyping|Dietary Supplement: Drug intake Hypertension University Hospital Clermont-Ferrand January 2022 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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