Home Immunology & Inflammation NOS inhibitor - TNF-alpha inhibitor - Interleukins inhibitor - JNK inhibitor - ERK inhibitor - STAT inhibitor (3R,8S)-Falcarindiol

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(3R,8S)-Falcarindiol NOS inhibitor

Cat.No.S3292

Falcarindiol (FAD, (3R,8S)-Falcarindiol, FaDOH) is a natural polyacetylene compound found rich in many plants of the Umbelliferae family. Falcarindiol suppresses LPS-stimulated expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β). Falcarindiol attenuates the LPS-induced activation of JNK, ERK, STAT1, and STAT3 signaling molecules.
(3R,8S)-Falcarindiol NOS inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 260.37

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Quality Control

Chemical Information, Storage & Stability

Molecular Weight 260.37 Formula

C17H24O2

 Storage (From the date of receipt) 2 years -20°C liquid
CAS No. 225110-25-8 -- Storage of Stock Solutions

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Mechanism of Action

Targets/IC50/Ki
iNOS [1]
TNFα [1]
IL-6 [1]
IL-1β [1]
JNK [1]
ERK [1]
STAT [1]
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06312410 Not yet recruiting
Child|Parents|Mental Disorder|Child of Impaired Parents|Preventive Health Services
Mental Health Services in the Capital Region Denmark|Aalborg Psychiatric Hospital|TrygFonden Denmark|Novo Nordisk A/S|Lundbeck Foundation|Liljeborgfonden|Ebbefos Fonden|KV Fonden
 March 18 2024 Not Applicable
NCT06159894 Not yet recruiting
HIV Infections
Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
 December 2023 Not Applicable

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