Hordenine

Catalog No.S2385

For research use only.

Hordenine (N,N-dimethyl-4-hydroxyphenylethylamine) is a phenylethylamine alkaloid with antibacterial and antibiotic properties.

Hordenine Chemical Structure

CAS No. 539-15-1

Purity & Quality Control

Choose Selective Bacterial Inhibitors

Biological Activity

Description Hordenine (N,N-dimethyl-4-hydroxyphenylethylamine) is a phenylethylamine alkaloid with antibacterial and antibiotic properties.
In vitro

Hordenine (N,N-dimethyl-4-hydroxyphenylethylamine) is a phenylethylamine alkaloid with antibacterial and antibiotic properties. It inhibits the uptake of norepinephrine in mammals, working as a stimulant. It is produced in nature by several varieties of plants in the family Cactaceae and by some in Acacia. [1] Recent study shows that hordenine may be an effective inhibitor of hyperpigmentation. it inhibits melanogenesis by suppressing cAMP production, which is involved in the expression of melanogenesis-related proteins. [2]

In vivo LD50: Mice 113.5mg/kg [3]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 33 mg/mL
(199.72 mM)
Ethanol 33 mg/mL
(199.72 mM)
Water Insoluble

Chemical Information

Molecular Weight 165.23
Formula

C10H15NO

CAS No. 539-15-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN(C)CCC1=CC=C(C=C1)O

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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