Hematoxylin

Catalog No.S2384 Synonyms: Hydroxybrazilin

For research use only.

Hematoxylin (Hydroxybrazilin) is a compound that forms strongly colored complexes with certain metal ions, notably Fe(III) and Al(III) salts and a kind of stain in histology.

Hematoxylin Chemical Structure

CAS No. 517-28-2

Selleck's Hematoxylin has been cited by 5 Publications

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Biological Activity

Description Hematoxylin (Hydroxybrazilin) is a compound that forms strongly colored complexes with certain metal ions, notably Fe(III) and Al(III) salts and a kind of stain in histology.
In vitro

Hematoxylin(Hydroxybrazilin) is a compound that forms strongly colored complexes with certain metal ions, notably Fe(III) and Al(III) salts and a kind of stain in histology. It is extracted from the bark of the logwood tree. Metal-haematein complexes are used to stain cell nuclei prior to examination under a microscope. Structures that stain with iron- or aluminium-haematein are often called basophilic, even though the mechanism of the staining is different from that of staining with basic dyes. Haematoxylin and eosin stain is one of the most commonly used stains in histology. [1]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 61 mg/mL
(201.79 mM)
Water 61 mg/mL
(201.79 mM)
Ethanol 61 mg/mL
(201.79 mM)

Chemical Information

Molecular Weight 302.28
Formula

C16H14O6

CAS No. 517-28-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1C2=CC(=C(C=C2C3C1(COC4=C3C=CC(=C4O)O)O)O)O

In vivo Formulation Calculator (Clear solution)

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% DMSO % % Tween 80 % ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04793230 Completed Diagnostic Test: biopsying Dacryocystitis; Chronic Al-Azhar University January 1 2019 --
NCT03483935 Completed Other: Microwave treatment Actinic Keratoses|Precancerous Skin Lesion University of Dundee|Emblation Limited March 7 2018 Not Applicable
NCT03085225 Active not recruiting Drug: Combination of trabectedin with durvalumab Ovarian Carcinoma|Soft Tissue Sarcoma Institut Bergonié|AstraZeneca|PharmaMar May 5 2017 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

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