Ingenol

Catalog No.S9101

For research use only.

Ingenol, a plant-derived diterpenoid, is a weak PKC activator and possesses important anticancer activity.

Ingenol Chemical Structure

CAS No. 30220-46-3

Selleck's Ingenol has been cited by 1 Publication

Purity & Quality Control

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Biological Activity

Description Ingenol, a plant-derived diterpenoid, is a weak PKC activator and possesses important anticancer activity.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 69 mg/mL
(198.03 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 348.43
Formula

C20H28O5

CAS No. 30220-46-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1CC2C(C2(C)C)C3C=C(C(C4(C1(C3=O)C=C(C4O)C)O)O)CO

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01836367 Completed Drug: Ingenol Mebutate 0.015% Actinic Keratosis Icahn School of Medicine at Mount Sinai|LEO Pharma March 2013 Phase 1
NCT01803477 Completed Drug: once daily for two consecutive days (Picato) Actinic Keratosis LEO Pharma February 2013 Phase 1|Phase 2
NCT01703078 Completed Drug: Ingenol once daily for two consecutive days Actinic Keratosis LEO Pharma November 2012 Phase 1
NCT00852137 Completed Drug: PEP005 (ingenol mebutate) Gel 0.05%|Drug: Vehicle Gel Actinic Keratosis Peplin March 2009 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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