Hydroxytyrosol Acetate

Catalog No.S3848 Synonyms: HTy-Ac

For research use only.

Hydroxytyrosol acetate (HTy-Ac), an extra virgin olive oil (EVOO) polyphenol, exhibits antioxidant and anti-inflammatory effects.

Hydroxytyrosol Acetate Chemical Structure

CAS No. 69039-02-7

Purity & Quality Control

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Biological Activity

Description Hydroxytyrosol acetate (HTy-Ac), an extra virgin olive oil (EVOO) polyphenol, exhibits antioxidant and anti-inflammatory effects.
In vitro

Hydroxytyrosol acetate significantly preventes t-BHP-induced OPA1 cleavage as well as the induction of Afg3l2. The significant morphology change in mitochondria induced by t-BHP is also normalized by Hydroxytyrosol acetate. Analysis of mitochondrial function reveals significant protection by hydroxytyrosol acetate on mitochondrial basal, maximal, spare respiration and complex activities. Hydroxytyrosol acetate works as an effective nutrient preventing OPA1 cleavage, mitochondrial dysfunction and muscle cell degeneration[2].

In vivo Hydroxytyrosol acetate administered orally inhibits platelet aggregation in rats and that a decrease in thromboxane synthesis along with an increase in nitric oxide production contribute to this effect[1].

Protocol (from reference)

Cell Research:[2]
  • Cell lines: C2C12 cell
  • Concentrations: 1, 10 and 50 μM
  • Incubation Time: 24 h
  • Method: C2C12 myotubes are treated with Hydroxytyrosol acetate at doses of 1, 10 and 50 μM for 24 h, followed by 100 μM t-BHP for an additional 24 h. The protective effects of Hydroxytyrosol acetate on mitochondrial membrane potential and cell viability are analyzed.
Animal Research:[1]
  • Animal Models: Male Wistar rats
  • Dosages: 1, 5, 10, 20, 50, and 100 mg/kg per day
  • Administration: p.o.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 196.20
Formula

C10H12O4

CAS No. 69039-02-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(=O)OCCC1=CC(=C(C=C1)O)O

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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