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Hydroxytyrosol Acetate

Cat.No.S3848

Hydroxytyrosol acetate (HTy-Ac), an extra virgin olive oil (EVOO) polyphenol, exhibits antioxidant and anti-inflammatory effects.
Hydroxytyrosol Acetate Chemical Structure

Chemical Structure

Molecular Weight: 196.20

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Quality Control

Batch: S384801 DMSO]39 mg/mL]false]]]false]]]false Purity: 99.66%
99.66

Solubility

In vitro
Batch:

DMSO : 39 mg/mL (198.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

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In vivo
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 196.20 Formula

C10H12O4

 Storage (From the date of receipt)
CAS No. 69039-02-7 Download SDF Storage of Stock Solutions

Synonyms HTy-Ac Smiles CC(=O)OCCC1=CC(=C(C=C1)O)O

Mechanism of Action

In vitro
Hydroxytyrosol acetate significantly preventes t-BHP-induced OPA1 cleavage as well as the induction of Afg3l2. The significant morphology change in mitochondria induced by t-BHP is also normalized by Hydroxytyrosol acetate. Analysis of mitochondrial function reveals significant protection by hydroxytyrosol acetate on mitochondrial basal, maximal, spare respiration and complex activities. Hydroxytyrosol acetate works as an effective nutrient preventing OPA1 cleavage, mitochondrial dysfunction and muscle cell degeneration.
In vivo
Hydroxytyrosol acetate administered orally inhibits platelet aggregation in rats and that a decrease in thromboxane synthesis along with an increase in nitric oxide production contribute to this effect.
References

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