Lycorine hydrochloride

Catalog No.S3800 Synonyms: Galanthidine hydrochloride, Amarylline hydrochloride, Narcissine hydrochloride, Licorine hydrochloride

For research use only.

Lycorine (Galanthidine, Amarylline, Narcissine, Licorine), a natural alkaloid extracted from the Amaryllidaceae plant family, has been reported to exhibit a wide range of physiological effects, including the potential effect against cancer. It is an HCV inhibitor with strong activity.

Lycorine hydrochloride Chemical Structure

CAS No. 2188-68-3

Selleck's Lycorine hydrochloride has been cited by 1 Publication

Purity & Quality Control

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Biological Activity

Description Lycorine (Galanthidine, Amarylline, Narcissine, Licorine), a natural alkaloid extracted from the Amaryllidaceae plant family, has been reported to exhibit a wide range of physiological effects, including the potential effect against cancer. It is an HCV inhibitor with strong activity.
In vitro

Lycorine not only possesses strong pharmacological effects on many diseases, including anti-leukemia, anti-tumor, anti-angiogenesis, anti-virus, anti-bacteria, anti-inflammation, and anti-malaria, but also exerts many other biological functions, such as inhibition of acetylcholinesterase and topoisomerase, suppression of ascorbic acid biosynthesis, and control of circadian period length. Lycorine inhibits cell proliferation and induces cell apoptosis in acute myeloid leukemia (AML) cell line HL-60, monocyte leukemia cell line U937, and T-cell leukemia cell line Jurkat. Lycorine also blocks multiple myeloma KM3 cell cycle, induces K562 cell-cycle arrest at the G0/G1 phase and suppresses tumorigenesis and the growth of various tumor cells, including melanoma C8161, ovarian cancer Hey1B, lung cancer A549, glioblatatoma U373, and esophageal cancer OE21[1]. Lycorine can inhibit protein synthesis in eukaryotic cells, and acetylcholinesterase activity[2].

In vivo Lycorine exhibits its numerous pharmacological effects on various diseases with very low toxicity and mild side effects. In vivo studies, lycorine effectively inhibits tumor growth in several mouse xenograft models. It effectively inhibits tumor neovascularization. Lycorine has trivial toxicity to normal cells and normal bodies. The animal toxicological experiments show that the 50% lethal death rate (LD50) of lycorine in mice is 112.2±0.024 mg/kg via intraperitoneal injection. The LD50 of lycorine in mice is 344 mg/kg via gastric lavage injection, suggesting that lycorine is very low toxicity in gastrointestinal administration. In vivo studies show that lycorine has linear plasma kinetics with a mean elimination half-life of 0.67 and 0.3 h after single s.c. and i.v. administration, respectively. The mean oral bioavailability is calculated to be about 40%. Biochemical and hematological parameters of safety studies indicate no pathological signs[1].

Protocol (from reference)

Cell Research:[3]
  • Cell lines: K562 cells
  • Concentrations: 2.5 or 5.0 μM
  • Incubation Time: 24 h
  • Method: --
  • (Only for Reference)
Animal Research:[2]
  • Animal Models: SCID mice inoculated with HL-60 cells
  • Dosages: 5 or 10 mg/kg/day
  • Administration: i.p.
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 64 mg/mL
(197.67 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 323.77
Formula

C16H17NO4.HCl

CAS No. 2188-68-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CN2CC3=CC4=C(C=C3C5C2C1=CC(C5O)O)OCO4.Cl

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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