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Fumaric acid

Name: Fumaric acid
Brand: Selleck Chemicals
SKU: S4952
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S4952

Fumaric acid (Fumarate, 2-Butenedioic acid, Trans-Butenedioic acid) is an intermediate in the citric acid cycle used by cells to produce energy in the form of adenosine triphosphate (ATP) from food; also a product of the urea cycle.

Chemical Structure

Molecular Weight: 116.07

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Quality Control

Batch: S495201 DMSO]23 mg/mL]false]Ethanol]20 mg/mL]false]Water]3.5 mg/mL]false Purity: 98%

Cited in Nature Medicine for its top-tier quality
COA
SDS
Datasheet

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Solubility

In vitro
Batch:

DMSO : 23 mg/mL (198.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 20 mg/mL

Water : 3.5 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	116.07	Formula	C₄H₄O₄	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	110-17-8	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	2-Butenedioic acid, Trans-Butenedioic acid, Allomaleic acid, Boletic acid, Donitic acid, Lichenic acid, Fumarate			Smiles	C(=CC(=O)O)C(=O)O

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05567458	Recruiting	Beta-thalassemia	Bristol-Myers Squibb	October 17 2022	Phase 2
NCT05278559	Enrolling by invitation	HIV/AIDS	Centre for Sexual Health and HIV/AIDS Research Zimbabwe\|European and Developing Countries Clinical Trials Partnership (EDCTP)	March 24 2022	--
NCT05247034	Recruiting	Diabetic Neuropathies	Anahuac University\|Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado	June 4 2021	Not Applicable
NCT04208529	Enrolling by invitation	Beta-Thalassemia\|Thalassemia\|Sickle Cell Disease\|Hematologic Diseases\|Hemoglobinopathies\|Genetic Diseases Inborn\|Sickle Cell Anemia	Vertex Pharmaceuticals Incorporated\|CRISPR Therapeutics	January 20 2021	Phase 3

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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